Serological immunoreactivity against colon cancer proteome varies upon disease progression

Lucia De Monte; Francesca Sanvito; Stefano Olivieri; Fiammetta Viganò; Claudio Doglioni; Matteo Frasson; Marco Braga; Angela Bachi; Paolo Dellabona; Maria Pia Protti; Massimo Alessio

doi:10.1021/pr070360m

Serological immunoreactivity against colon cancer proteome varies upon disease progression

Lucia De Monte, Francesca Sanvito, Stefano Olivieri, Fiammetta Viganò, Claudio Doglioni, Matteo Frasson, Marco Braga, Angela Bachi, Paolo Dellabona, Maria Pia Protti, Massimo Alessio

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Sera from colon carcinoma patients were used to identify tumor-associated antigens (TAAs) by screening tumor proteome resolved by 2D electrophoresis. A panel of six TAAs eliciting a serological immune response in colorectal cancer was identified, showing a modification in antigen recognition by B cells in patients as a function of colon cancer progression. The expression of these proteins was either confined or increased in tumor as compared to normal mucosa.

Original language	English
Pages (from-to)	504-514
Number of pages	11
Journal	Journal of Proteome Research
Volume	7
Issue number	2
DOIs	https://doi.org/10.1021/pr070360m
Publication status	Published - Feb 2008

Keywords

2D electrophoresis
Colorectal carcinoma
Proteomics
Tumor-associated antigens

ASJC Scopus subject areas

Genetics
Biotechnology
Biochemistry

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10.1021/pr070360m

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title = "Serological immunoreactivity against colon cancer proteome varies upon disease progression",

abstract = "Sera from colon carcinoma patients were used to identify tumor-associated antigens (TAAs) by screening tumor proteome resolved by 2D electrophoresis. A panel of six TAAs eliciting a serological immune response in colorectal cancer was identified, showing a modification in antigen recognition by B cells in patients as a function of colon cancer progression. The expression of these proteins was either confined or increased in tumor as compared to normal mucosa.",

keywords = "2D electrophoresis, Colorectal carcinoma, Proteomics, Tumor-associated antigens",

author = "{De Monte}, Lucia and Francesca Sanvito and Stefano Olivieri and Fiammetta Vigan{\`o} and Claudio Doglioni and Matteo Frasson and Marco Braga and Angela Bachi and Paolo Dellabona and Protti, {Maria Pia} and Massimo Alessio",

year = "2008",

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doi = "10.1021/pr070360m",

language = "English",

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T1 - Serological immunoreactivity against colon cancer proteome varies upon disease progression

AU - De Monte, Lucia

AU - Sanvito, Francesca

AU - Olivieri, Stefano

AU - Viganò, Fiammetta

AU - Doglioni, Claudio

AU - Frasson, Matteo

AU - Braga, Marco

AU - Bachi, Angela

AU - Dellabona, Paolo

AU - Protti, Maria Pia

AU - Alessio, Massimo

PY - 2008/2

Y1 - 2008/2

N2 - Sera from colon carcinoma patients were used to identify tumor-associated antigens (TAAs) by screening tumor proteome resolved by 2D electrophoresis. A panel of six TAAs eliciting a serological immune response in colorectal cancer was identified, showing a modification in antigen recognition by B cells in patients as a function of colon cancer progression. The expression of these proteins was either confined or increased in tumor as compared to normal mucosa.

AB - Sera from colon carcinoma patients were used to identify tumor-associated antigens (TAAs) by screening tumor proteome resolved by 2D electrophoresis. A panel of six TAAs eliciting a serological immune response in colorectal cancer was identified, showing a modification in antigen recognition by B cells in patients as a function of colon cancer progression. The expression of these proteins was either confined or increased in tumor as compared to normal mucosa.

KW - 2D electrophoresis

KW - Colorectal carcinoma

KW - Proteomics

KW - Tumor-associated antigens

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DO - 10.1021/pr070360m

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SN - 1535-3893

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SP - 504

EP - 514

JO - Journal of Proteome Research

JF - Journal of Proteome Research

IS - 2

ER -

Serological immunoreactivity against colon cancer proteome varies upon disease progression

Abstract

Keywords

ASJC Scopus subject areas

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