Sera from colon carcinoma patients were used to identify tumor-associated antigens (TAAs) by screening tumor proteome resolved by 2D electrophoresis. A panel of six TAAs eliciting a serological immune response in colorectal cancer was identified, showing a modification in antigen recognition by B cells in patients as a function of colon cancer progression. The expression of these proteins was either confined or increased in tumor as compared to normal mucosa.
|Number of pages||11|
|Journal||Journal of Proteome Research|
|Publication status||Published - Feb 2008|
- 2D electrophoresis
- Colorectal carcinoma
- Tumor-associated antigens
ASJC Scopus subject areas