Serologic markers of Chlamydia trachomatis and other sexually transmitted infections and subsequent ovarian cancer risk: Results from the EPIC cohort.

Annika Idahl; Charlotte Le Cornet; Sandra González Maldonado; Tim Waterboer; Noemi Bender; Anne Tjønneland; Louise Hansen; Marie-Christine Boutron-Ruault; Agnès Fournier; Marina Kvaskoff; Heiner Boeing; Antonia Trichopoulou; Elisavet Valanou; Eleni Peppa; Domenico Palli; Claudia Agnoli; Amalia Mattiello; Rosario Tumino; Carlotta Sacerdote; N. Charlotte Onland-Moret; Inger T. Gram; Elisabete Weiderpass; Jose R. Quirós; Eric J. Duell; Maria-Jose Sánchez; Maria-Dolores Chirlaque; Aurelio Barricarte; Leire Gil; Jenny Brändstedt; Kristian Riesbeck; Eva Lundin; Kay-Tee Khaw; Aurora Perez-Cornago; Marc J. Gunter; Laure Dossus; Rudolf Kaaks; Renée T. Fortner

Serologic markers of Chlamydia trachomatis and other sexually transmitted infections and subsequent ovarian cancer risk: Results from the EPIC cohort.

Annika Idahl, Charlotte Le Cornet, Sandra González Maldonado, Tim Waterboer, Noemi Bender, Anne Tjønneland, Louise Hansen, Marie-Christine Boutron-Ruault, Agnès Fournier, Marina Kvaskoff, Heiner Boeing, Antonia Trichopoulou, Elisavet Valanou, Eleni Peppa, Domenico Palli, Claudia Agnoli, Amalia Mattiello, Rosario Tumino, Carlotta Sacerdote, N. Charlotte Onland-MoretInger T. Gram, Elisabete Weiderpass, Jose R. Quirós, Eric J. Duell, Maria-Jose Sánchez, Maria-Dolores Chirlaque, Aurelio Barricarte, Leire Gil, Jenny Brändstedt, Kristian Riesbeck, Eva Lundin, Kay-Tee Khaw, Aurora Perez-Cornago, Marc J. Gunter, Laure Dossus, Rudolf Kaaks, Renée T. Fortner

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

A substantial proportion of epithelial ovarian cancer (EOC) arises in the fallopian tube and other epithelia of the upper genital tract; these epithelia may incur damage and neoplastic transformation after sexually transmitted infections (STI) and pelvic inflammatory disease. We investigated the hypothesis that past STI infection, particularly Chlamydia trachomatis, is associated with higher EOC risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort including 791 cases and 1669 matched controls. Serum antibodies against C. trachomatis, Mycoplasma genitalium, herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) 16, 18 and 45 were assessed using multiplex fluorescent bead-based serology. Conditional logistic regression was used to estimate relative risks (RR) and 95CI) comparing women with positive vs. negative serology. A total of 40 antibodies was not associated with EOC risk overall, but with higher risk of the mucinous histotype (RR = 2.30 [95.22-4.32]). Positive serology for chlamydia heat shock protein 60 (cHSP60-1) was associated with higher risk of EOC overall (1.36 [1.13-1.64]) and with the serous subtype (1.44 [1.12-1.85]). None of the other evaluated STIs were associated with EOC risk overall; however, HSV-2 was associated with higher risk of endometrioid EOC (2.35 [1.24-4.43]). The findings of our study suggest a potential role of C. trachomatis in the carcinogenesis of serous and mucinous EOC, while HSV-2 might promote the development of endometrioid disease.

Original language	English
Journal	International Journal of Cancer
Issue number	8
Publication status	Published - Oct 1 2020

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Idahl, A., Le Cornet, C., González Maldonado, S., Waterboer, T., Bender, N., Tjønneland, A., Hansen, L., Boutron-Ruault, M-C., Fournier, A., Kvaskoff, M., Boeing, H., Trichopoulou, A., Valanou, E., Peppa, E., Palli, D., Agnoli, C., Mattiello, A., Tumino, R., Sacerdote, C., ... Fortner, R. T. (2020). Serologic markers of Chlamydia trachomatis and other sexually transmitted infections and subsequent ovarian cancer risk: Results from the EPIC cohort. International Journal of Cancer, (8).

Idahl, A, Le Cornet, C, González Maldonado, S, Waterboer, T, Bender, N, Tjønneland, A, Hansen, L, Boutron-Ruault, M-C, Fournier, A, Kvaskoff, M, Boeing, H, Trichopoulou, A, Valanou, E, Peppa, E, Palli, D, Agnoli, C, Mattiello, A, Tumino, R, Sacerdote, C, Onland-Moret, NC, Gram, IT, Weiderpass, E, Quirós, JR, Duell, EJ, Sánchez, M-J, Chirlaque, M-D, Barricarte, A, Gil, L, Brändstedt, J, Riesbeck, K, Lundin, E, Khaw, K-T, Perez-Cornago, A, Gunter, MJ, Dossus, L, Kaaks, R & Fortner, RT 2020, 'Serologic markers of Chlamydia trachomatis and other sexually transmitted infections and subsequent ovarian cancer risk: Results from the EPIC cohort.', International Journal of Cancer, no. 8.

@article{f2500e5262c04d01ba24a8449e24226d,

title = "Serologic markers of Chlamydia trachomatis and other sexually transmitted infections and subsequent ovarian cancer risk: Results from the EPIC cohort.",

abstract = "A substantial proportion of epithelial ovarian cancer (EOC) arises in the fallopian tube and other epithelia of the upper genital tract; these epithelia may incur damage and neoplastic transformation after sexually transmitted infections (STI) and pelvic inflammatory disease. We investigated the hypothesis that past STI infection, particularly Chlamydia trachomatis, is associated with higher EOC risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort including 791 cases and 1669 matched controls. Serum antibodies against C. trachomatis, Mycoplasma genitalium, herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) 16, 18 and 45 were assessed using multiplex fluorescent bead-based serology. Conditional logistic regression was used to estimate relative risks (RR) and 95CI) comparing women with positive vs. negative serology. A total of 40 antibodies was not associated with EOC risk overall, but with higher risk of the mucinous histotype (RR = 2.30 [95.22-4.32]). Positive serology for chlamydia heat shock protein 60 (cHSP60-1) was associated with higher risk of EOC overall (1.36 [1.13-1.64]) and with the serous subtype (1.44 [1.12-1.85]). None of the other evaluated STIs were associated with EOC risk overall; however, HSV-2 was associated with higher risk of endometrioid EOC (2.35 [1.24-4.43]). The findings of our study suggest a potential role of C. trachomatis in the carcinogenesis of serous and mucinous EOC, while HSV-2 might promote the development of endometrioid disease.",

author = "Annika Idahl and {Le Cornet}, Charlotte and {Gonz{\'a}lez Maldonado}, Sandra and Tim Waterboer and Noemi Bender and Anne Tj{\o}nneland and Louise Hansen and Marie-Christine Boutron-Ruault and Agn{\`e}s Fournier and Marina Kvaskoff and Heiner Boeing and Antonia Trichopoulou and Elisavet Valanou and Eleni Peppa and Domenico Palli and Claudia Agnoli and Amalia Mattiello and Rosario Tumino and Carlotta Sacerdote and Onland-Moret, {N. Charlotte} and Gram, {Inger T.} and Elisabete Weiderpass and Quir{\'o}s, {Jose R.} and Duell, {Eric J.} and Maria-Jose S{\'a}nchez and Maria-Dolores Chirlaque and Aurelio Barricarte and Leire Gil and Jenny Br{\"a}ndstedt and Kristian Riesbeck and Eva Lundin and Kay-Tee Khaw and Aurora Perez-Cornago and Gunter, {Marc J.} and Laure Dossus and Rudolf Kaaks and Fortner, {Ren{\'e}e T.}",

note = "Place: United States",

year = "2020",

month = oct,

day = "1",

language = "English",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "Wiley-Liss Inc.",

number = "8",

}

TY - JOUR

T1 - Serologic markers of Chlamydia trachomatis and other sexually transmitted infections and subsequent ovarian cancer risk: Results from the EPIC cohort.

AU - Idahl, Annika

AU - Le Cornet, Charlotte

AU - González Maldonado, Sandra

AU - Waterboer, Tim

AU - Bender, Noemi

AU - Tjønneland, Anne

AU - Hansen, Louise

AU - Boutron-Ruault, Marie-Christine

AU - Fournier, Agnès

AU - Kvaskoff, Marina

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Valanou, Elisavet

AU - Peppa, Eleni

AU - Palli, Domenico

AU - Agnoli, Claudia

AU - Mattiello, Amalia

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Onland-Moret, N. Charlotte

AU - Gram, Inger T.

AU - Weiderpass, Elisabete

AU - Quirós, Jose R.

AU - Duell, Eric J.

AU - Sánchez, Maria-Jose

AU - Chirlaque, Maria-Dolores

AU - Barricarte, Aurelio

AU - Gil, Leire

AU - Brändstedt, Jenny

AU - Riesbeck, Kristian

AU - Lundin, Eva

AU - Khaw, Kay-Tee

AU - Perez-Cornago, Aurora

AU - Gunter, Marc J.

AU - Dossus, Laure

AU - Kaaks, Rudolf

AU - Fortner, Renée T.

N1 - Place: United States

PY - 2020/10/1

Y1 - 2020/10/1

N2 - A substantial proportion of epithelial ovarian cancer (EOC) arises in the fallopian tube and other epithelia of the upper genital tract; these epithelia may incur damage and neoplastic transformation after sexually transmitted infections (STI) and pelvic inflammatory disease. We investigated the hypothesis that past STI infection, particularly Chlamydia trachomatis, is associated with higher EOC risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort including 791 cases and 1669 matched controls. Serum antibodies against C. trachomatis, Mycoplasma genitalium, herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) 16, 18 and 45 were assessed using multiplex fluorescent bead-based serology. Conditional logistic regression was used to estimate relative risks (RR) and 95CI) comparing women with positive vs. negative serology. A total of 40 antibodies was not associated with EOC risk overall, but with higher risk of the mucinous histotype (RR = 2.30 [95.22-4.32]). Positive serology for chlamydia heat shock protein 60 (cHSP60-1) was associated with higher risk of EOC overall (1.36 [1.13-1.64]) and with the serous subtype (1.44 [1.12-1.85]). None of the other evaluated STIs were associated with EOC risk overall; however, HSV-2 was associated with higher risk of endometrioid EOC (2.35 [1.24-4.43]). The findings of our study suggest a potential role of C. trachomatis in the carcinogenesis of serous and mucinous EOC, while HSV-2 might promote the development of endometrioid disease.

AB - A substantial proportion of epithelial ovarian cancer (EOC) arises in the fallopian tube and other epithelia of the upper genital tract; these epithelia may incur damage and neoplastic transformation after sexually transmitted infections (STI) and pelvic inflammatory disease. We investigated the hypothesis that past STI infection, particularly Chlamydia trachomatis, is associated with higher EOC risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort including 791 cases and 1669 matched controls. Serum antibodies against C. trachomatis, Mycoplasma genitalium, herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) 16, 18 and 45 were assessed using multiplex fluorescent bead-based serology. Conditional logistic regression was used to estimate relative risks (RR) and 95CI) comparing women with positive vs. negative serology. A total of 40 antibodies was not associated with EOC risk overall, but with higher risk of the mucinous histotype (RR = 2.30 [95.22-4.32]). Positive serology for chlamydia heat shock protein 60 (cHSP60-1) was associated with higher risk of EOC overall (1.36 [1.13-1.64]) and with the serous subtype (1.44 [1.12-1.85]). None of the other evaluated STIs were associated with EOC risk overall; however, HSV-2 was associated with higher risk of endometrioid EOC (2.35 [1.24-4.43]). The findings of our study suggest a potential role of C. trachomatis in the carcinogenesis of serous and mucinous EOC, while HSV-2 might promote the development of endometrioid disease.

M3 - Article

SN - 0020-7136

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 8

ER -

Serologic markers of Chlamydia trachomatis and other sexually transmitted infections and subsequent ovarian cancer risk: Results from the EPIC cohort.

Abstract

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