TY - JOUR
T1 - Seminal vesicle protein IV and its derived active peptides
T2 - A possible physiological role in seminal clotting
AU - Metafora, Salvatore
AU - Esposito, Carla
AU - Caputo, Ivana
AU - Lepretti, Marilena
AU - Cassese, Diana
AU - Dicitore, Alessandra
AU - Ferranti, Pasquale
AU - Stiuso, Paola
PY - 2007/2
Y1 - 2007/2
N2 - Seminal vesicle protein 4 (SV-IV) is a highly flexible molecule that in aqueous solution behaves as a concentration-dependent self-associating system in which the degree of association (monomer ↔ dimer ↔ trimer equilibrium) seems to be related to its biological activities. This review reports the functional role of SV-IV in seminal clotting exerted through the modulation of inflammation, hemostasis, and sperm protection against the damage induced by immunological or reactive oxygen species during the long journey of spermatozoa in the female genital tract.
AB - Seminal vesicle protein 4 (SV-IV) is a highly flexible molecule that in aqueous solution behaves as a concentration-dependent self-associating system in which the degree of association (monomer ↔ dimer ↔ trimer equilibrium) seems to be related to its biological activities. This review reports the functional role of SV-IV in seminal clotting exerted through the modulation of inflammation, hemostasis, and sperm protection against the damage induced by immunological or reactive oxygen species during the long journey of spermatozoa in the female genital tract.
KW - Hemostatic factors
KW - Prostate transglutaminase
KW - Seminal clotting
KW - SV-IV protein
UR - http://www.scopus.com/inward/record.url?scp=33846617398&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846617398&partnerID=8YFLogxK
U2 - 10.1055/s-2006-958462
DO - 10.1055/s-2006-958462
M3 - Article
C2 - 17253190
AN - SCOPUS:33846617398
SN - 0094-6176
VL - 33
SP - 53
EP - 59
JO - Seminars in Thrombosis and Hemostasis
JF - Seminars in Thrombosis and Hemostasis
IS - 1
ER -