Selective transcriptional regulation by Myc: Experimental design and computational analysis of high-throughput sequencing data

Mattia Pelizzola; Marco J. Morelli; Arianna Sabò; Theresia R. Kress; Stefano de Pretis; Bruno Amati

doi:10.1016/j.dib.2015.02.003

Selective transcriptional regulation by Myc: Experimental design and computational analysis of high-throughput sequencing data

Mattia Pelizzola, Marco J. Morelli, Arianna Sabò, Theresia R. Kress, Stefano de Pretis, Bruno Amati

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

The gene expression programs regulated by the Myc transcription factor were evaluated by integrated genome-wide profiling of Myc binding sites, chromatin marks and RNA expression in several biological models. Our results indicate that Myc directly drives selective transcriptional regulation, which in certain physiological conditions may indirectly lead to RNA amplification. Here, we illustrate in detail the experimental design concerning the high-throughput sequencing data associated with our study (Sabò et al., Nature. (2014) 511:488-492) and the R scripts used for their computational analysis.

Original language	English
Pages (from-to)	40-46
Number of pages	7
Journal	Data in Brief
Volume	3
DOIs	https://doi.org/10.1016/j.dib.2015.02.003
Publication status	Published - May 1 2015

Keywords

B-cell lymphoma
Post-translational histone modifications
Transcription

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Education

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10.1016/j.dib.2015.02.003

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abstract = "The gene expression programs regulated by the Myc transcription factor were evaluated by integrated genome-wide profiling of Myc binding sites, chromatin marks and RNA expression in several biological models. Our results indicate that Myc directly drives selective transcriptional regulation, which in certain physiological conditions may indirectly lead to RNA amplification. Here, we illustrate in detail the experimental design concerning the high-throughput sequencing data associated with our study (Sab{\`o} et al., Nature. (2014) 511:488-492) and the R scripts used for their computational analysis.",

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AU - Kress, Theresia R.

AU - de Pretis, Stefano

AU - Amati, Bruno

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AB - The gene expression programs regulated by the Myc transcription factor were evaluated by integrated genome-wide profiling of Myc binding sites, chromatin marks and RNA expression in several biological models. Our results indicate that Myc directly drives selective transcriptional regulation, which in certain physiological conditions may indirectly lead to RNA amplification. Here, we illustrate in detail the experimental design concerning the high-throughput sequencing data associated with our study (Sabò et al., Nature. (2014) 511:488-492) and the R scripts used for their computational analysis.

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KW - Transcription

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Selective transcriptional regulation by Myc: Experimental design and computational analysis of high-throughput sequencing data

Abstract

Keywords

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