Seizures can precede cognitive symptoms in late-onset Alzheimer's disease

Agnese Picco; Silvana Archetti; Michela Ferrara; Dario Arnaldi; Alessandra Piccini; Carlo Serrati; Diego Di Lorenzo; Silvia Morbelli; Flavio Nobili

doi:10.3233/JAD-2011-110896

Seizures can precede cognitive symptoms in late-onset Alzheimer's disease

Agnese Picco, Silvana Archetti, Michela Ferrara, Dario Arnaldi, Alessandra Piccini, Carlo Serrati, Diego Di Lorenzo, Silvia Morbelli, Flavio Nobili

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

This study describes late-onset Alzheimer's disease (LOAD) in the mild cognitive impairment (MCI) stage, debuting with seizures in a 72 year-old woman. Prodromal AD was consistently diagnosed with four among amyloidosis and neurodegeneration biomarkers about 1 year after onset of seizures. Genetic assessment demonstrated apolipoprotein E ε2/ε3 genotype and three intronic single nucleotide substitutions, two in presenilin 1 and one in amyloid-β protein precursor genes. This case of seizures at onset of LOAD with severe signs of brain amyloidosis and neurodegeneration but with just MCI leads to a re-appraisal of the intriguing relationship between AD pathology and neuron excitability in humans.

Original language	English
Pages (from-to)	737-742
Number of pages	6
Journal	Journal of Alzheimer's Disease
Volume	27
Issue number	4
DOIs	https://doi.org/10.3233/JAD-2011-110896
Publication status	Published - 2011

Keywords

Alzheimer's disease
amyloid-β protein precursor
biological markers
presenilins
seizures

ASJC Scopus subject areas

Psychiatry and Mental health
Geriatrics and Gerontology
Clinical Psychology

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10.3233/JAD-2011-110896

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title = "Seizures can precede cognitive symptoms in late-onset Alzheimer's disease",

abstract = "This study describes late-onset Alzheimer's disease (LOAD) in the mild cognitive impairment (MCI) stage, debuting with seizures in a 72 year-old woman. Prodromal AD was consistently diagnosed with four among amyloidosis and neurodegeneration biomarkers about 1 year after onset of seizures. Genetic assessment demonstrated apolipoprotein E ε2/ε3 genotype and three intronic single nucleotide substitutions, two in presenilin 1 and one in amyloid-β protein precursor genes. This case of seizures at onset of LOAD with severe signs of brain amyloidosis and neurodegeneration but with just MCI leads to a re-appraisal of the intriguing relationship between AD pathology and neuron excitability in humans.",

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AU - Picco, Agnese

AU - Archetti, Silvana

AU - Ferrara, Michela

AU - Arnaldi, Dario

AU - Piccini, Alessandra

AU - Serrati, Carlo

AU - Di Lorenzo, Diego

AU - Morbelli, Silvia

AU - Nobili, Flavio

PY - 2011

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Seizures can precede cognitive symptoms in late-onset Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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