Seizures can precede cognitive symptoms in late-onset Alzheimer's disease

Agnese Picco, Silvana Archetti, Michela Ferrara, Dario Arnaldi, Alessandra Piccini, Carlo Serrati, Diego Di Lorenzo, Silvia Morbelli, Flavio Nobili

Research output: Contribution to journalArticlepeer-review


This study describes late-onset Alzheimer's disease (LOAD) in the mild cognitive impairment (MCI) stage, debuting with seizures in a 72 year-old woman. Prodromal AD was consistently diagnosed with four among amyloidosis and neurodegeneration biomarkers about 1 year after onset of seizures. Genetic assessment demonstrated apolipoprotein E ε2/ε3 genotype and three intronic single nucleotide substitutions, two in presenilin 1 and one in amyloid-β protein precursor genes. This case of seizures at onset of LOAD with severe signs of brain amyloidosis and neurodegeneration but with just MCI leads to a re-appraisal of the intriguing relationship between AD pathology and neuron excitability in humans.

Original languageEnglish
Pages (from-to)737-742
Number of pages6
JournalJournal of Alzheimer's Disease
Issue number4
Publication statusPublished - 2011


  • Alzheimer's disease
  • amyloid-β protein precursor
  • biological markers
  • presenilins
  • seizures

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology


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