Screening for congenital coagulation disorders.

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A thorough screening procedure to diagnose congenital coagulation disorders must start from a careful collection of the personal and family clinical history, followed by a two-step laboratory screening. The first step is aimed at detecting the most frequent and well established causes of hemorrhage by a simple battery of laboratory tests such as bleeding time, platelet count, prothrombin time and activated partial thromboplastin time. The second step is to be performed in case of a past history of bleeding, but normal first-step laboratory screening and is aimed at detecting the less frequent abnormalities of hemostasis such as factor XIII, antiplasmin, platelet factor 3, von Willebrand factor, tissue plasminogen activator and dysfibrinogenemia, to which the first-step screening tests are not sensitive.

Original languageEnglish
Pages (from-to)327-332
Number of pages6
JournalLa Ricerca in Clinica e in Laboratorio
Issue number4
Publication statusPublished - Oct 1989

ASJC Scopus subject areas

  • Clinical Biochemistry


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