Safety of Food Oral Immunotherapy: What We Know, and What We Need to Learn

Sonia Vázquez-Cortés, Paloma Jaqueti, Stefania Arasi, Adrianna Machinena, Montserrat Alvaro-Lozano, Montserrat Fernández-Rivas

Research output: Contribution to journalReview articlepeer-review


Oral immunotherapy (OIT) for food allergy entails a risk of adverse reactions, including anaphylaxis. This safety concern is the major barrier for OIT to become a therapeutic option in clinical practice. The high heterogeneity in safety reporting of OIT studies prevents setting the safety profile accurately. An international consensus is needed to facilitate the analysis of large pooled clinical data with homogeneous safety reporting, that together with integrated omics, and patients/families’ opinions, may help stratify the patients’ risk and needs, and help developing safe(r) individualized care pathways. This will give OIT the right place in the food allergy therapy.

Original languageEnglish
Pages (from-to)111-133
Number of pages23
JournalImmunology and Allergy Clinics of North America
Issue number1
Publication statusE-pub ahead of print - 2019


  • Allergy
  • Food
  • Immunotherapy
  • Oral immunotherapy
  • Safety

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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