Routine chromosome analysis on fetal blood microaliquots obtained at fetoscopy

G. Simoni, M. G. Tibiletti, L. Dalpra, M. Ferrari, B. Brambati

Research output: Contribution to journalArticlepeer-review


A routine study of the fetal karyotype was performed on samples obtained at 64 fetoscopic procedures. In 13 cases only pure amniotic fluid was available for the cultures, while in the remaining 51 cases the chromosome analysis was carried out on PHA-stimulated lymphocyte microcultures set up with any excess fetal blood above the requirements for globin-chain synthesis. Karyotype could be determined on fetal lymphocytes in 44 cases (86 per cent). All the fetuses were chromosomally normal. This experience shows that cytogenetic analysis using microaliquots of fetal blood is a relatively simple technique which should be introduced into routine prenatal diagnosis by fetoscopy.

Original languageEnglish
Pages (from-to)203-208
Number of pages6
JournalPrenatal Diagnosis
Issue number3
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Genetics(clinical)
  • Obstetrics and Gynaecology


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