Role of the HLA class II: HCV-related disorders

Valli De Re, Laura Caggiari, Maria Paola Simula, Salvatore De Vita, Cesare Mazzaro, Marco Lenzi, Massimo Galli M., Giuseppe Monti, Clodoveo Ferri, Anna Linda Zignego, Armando Gabrielli, Domenico Sansonno, Franco Dammacco, Massimo Libra, Nicoletta Sacchi, Renato Talamini, Michele Spina, Umberto Tirelli, Renato Cannizzaro, Riccardo Dolcetti

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The paper highlights the role of different HLA class II molecules in hepatic and lymphoproliferative HCV-related disorders. HLA molecules have been reviewed, according to an in silico cluster classification, based on the sequence, the biochemical structure of the pockets, and the functional characteristics of the HLA II molecules. Thus, by reducing the complexity of HLA II polymorphism, charateristics that unite different HLA molecules with specific HCV-associated pathologies may be recognized with greater case. Results show that HLA clusters associated with better dlimination of the virus are protective against HCC development, while the same clusters are associated with a higher risk of developing cryoglobulinemic syndrome and the concomitant NHL. These data added further acknowledgements on pathogenetic mechanisms associated with HCV infection. Results also highlight differences of NHL occurring in HCV-positive subjects, with or without a concomitant type II autoimmune cryoglobulinemic syndrome, suggesting that cryoglobulinemic background associated with NHL should be considered in the evaluation of the effectiveness of new therapies in the course of HCV-associated NHLs.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Number of pages11
Publication statusPublished - Jun 2007

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)00778923
ISSN (Electronic)17496632


  • B-cell lymphoproliferation
  • Cryoglobulinemia
  • Hepatitis C virus
  • Hepatocarcinoma
  • HLA DQB1
  • HLA DRB1
  • Lymphoma
  • MHC allele
  • SBT
  • Sequence-based typing

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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