Role of palatine tonsillectomy in the diagnostic workup of head and neck squamous cell carcinoma of unknown primary origin: A systematic review and meta-analysis

Pasquale Di Maio; Oreste Iocca; Armando De Virgilio; Fabio Ferreli; Giovanni Cristalli; Raul Pellini; Pawel Golusinski; Giampietro Ricci; Giuseppe Spriano

doi:10.1002/hed.25522

Role of palatine tonsillectomy in the diagnostic workup of head and neck squamous cell carcinoma of unknown primary origin: A systematic review and meta-analysis

Pasquale Di Maio, Oreste Iocca, Armando De Virgilio, Fabio Ferreli, Giovanni Cristalli, Raul Pellini, Pawel Golusinski, Giampietro Ricci, Giuseppe Spriano

Research output: Contribution to journal › Review article › peer-review

Abstract

BACKGROUND: This systematic review and meta-analysis aims to evaluate the effectiveness of palatine tonsillectomy in patients with cervical metastasis from squamous cell carcinoma of unknown primary (SCCUP) origin.

METHODS: A systematic review including studies that encompassed palatine tonsillectomy in the SSCUP diagnostic evaluation was conducted. A single arm meta-analysis was then made to obtain the overall identification rate of tonsillectomy.

RESULTS: Fourteen studies were included, comprising 673 patients who underwent 416 palatine tonsillectomies, 338 preformed during examination under anesthesia (EUA) and 78 managed with transoral robotic surgery (TORS). A total of 140 occult tonsillar malignancies were identified; of these, 124 (89%) were ipsilateral, 2 (1%) contralateral, and 14 (10%) synchronous bilateral. Meta-analysis of 11 studies showed an overall detection rate of tonsillectomy of 0.34 (99% confidence interval 0.23-0.46).

CONCLUSION: Palatine tonsillectomy is a valuable diagnostic tool in the management of patients with head and neck SCCUP. Bilaterality of tonsillectomy should be taken into consideration.

Original language	English
Pages (from-to)	1112-1121
Number of pages	10
Journal	Head and Neck Surgery
Volume	41
Issue number	4
DOIs	https://doi.org/10.1002/hed.25522
Publication status	Published - Apr 2019

Access to Document

10.1002/hed.25522

Cite this

Di Maio, P, Iocca, O, De Virgilio, A, Ferreli, F, Cristalli, G, Pellini, R, Golusinski, P, Ricci, G & Spriano, G 2019, 'Role of palatine tonsillectomy in the diagnostic workup of head and neck squamous cell carcinoma of unknown primary origin: A systematic review and meta-analysis', Head and Neck Surgery, vol. 41, no. 4, pp. 1112-1121. https://doi.org/10.1002/hed.25522

@article{962ac5022b48407b95678977d5240f5a,

title = "Role of palatine tonsillectomy in the diagnostic workup of head and neck squamous cell carcinoma of unknown primary origin: A systematic review and meta-analysis",

abstract = "BACKGROUND: This systematic review and meta-analysis aims to evaluate the effectiveness of palatine tonsillectomy in patients with cervical metastasis from squamous cell carcinoma of unknown primary (SCCUP) origin.METHODS: A systematic review including studies that encompassed palatine tonsillectomy in the SSCUP diagnostic evaluation was conducted. A single arm meta-analysis was then made to obtain the overall identification rate of tonsillectomy.RESULTS: Fourteen studies were included, comprising 673 patients who underwent 416 palatine tonsillectomies, 338 preformed during examination under anesthesia (EUA) and 78 managed with transoral robotic surgery (TORS). A total of 140 occult tonsillar malignancies were identified; of these, 124 (89%) were ipsilateral, 2 (1%) contralateral, and 14 (10%) synchronous bilateral. Meta-analysis of 11 studies showed an overall detection rate of tonsillectomy of 0.34 (99% confidence interval 0.23-0.46).CONCLUSION: Palatine tonsillectomy is a valuable diagnostic tool in the management of patients with head and neck SCCUP. Bilaterality of tonsillectomy should be taken into consideration.",

author = "{Di Maio}, Pasquale and Oreste Iocca and {De Virgilio}, Armando and Fabio Ferreli and Giovanni Cristalli and Raul Pellini and Pawel Golusinski and Giampietro Ricci and Giuseppe Spriano",

note = "{\textcopyright} 2018 Wiley Periodicals, Inc.",

year = "2019",

month = apr,

doi = "10.1002/hed.25522",

language = "English",

volume = "41",

pages = "1112--1121",

journal = "Head and Neck Surgery",

issn = "1043-3074",

publisher = "Wiley-Liss Inc.",

number = "4",

}

TY - JOUR

T1 - Role of palatine tonsillectomy in the diagnostic workup of head and neck squamous cell carcinoma of unknown primary origin

T2 - A systematic review and meta-analysis

AU - Di Maio, Pasquale

AU - Iocca, Oreste

AU - De Virgilio, Armando

AU - Ferreli, Fabio

AU - Cristalli, Giovanni

AU - Pellini, Raul

AU - Golusinski, Pawel

AU - Ricci, Giampietro

AU - Spriano, Giuseppe

PY - 2019/4

Y1 - 2019/4

N2 - BACKGROUND: This systematic review and meta-analysis aims to evaluate the effectiveness of palatine tonsillectomy in patients with cervical metastasis from squamous cell carcinoma of unknown primary (SCCUP) origin.METHODS: A systematic review including studies that encompassed palatine tonsillectomy in the SSCUP diagnostic evaluation was conducted. A single arm meta-analysis was then made to obtain the overall identification rate of tonsillectomy.RESULTS: Fourteen studies were included, comprising 673 patients who underwent 416 palatine tonsillectomies, 338 preformed during examination under anesthesia (EUA) and 78 managed with transoral robotic surgery (TORS). A total of 140 occult tonsillar malignancies were identified; of these, 124 (89%) were ipsilateral, 2 (1%) contralateral, and 14 (10%) synchronous bilateral. Meta-analysis of 11 studies showed an overall detection rate of tonsillectomy of 0.34 (99% confidence interval 0.23-0.46).CONCLUSION: Palatine tonsillectomy is a valuable diagnostic tool in the management of patients with head and neck SCCUP. Bilaterality of tonsillectomy should be taken into consideration.

AB - BACKGROUND: This systematic review and meta-analysis aims to evaluate the effectiveness of palatine tonsillectomy in patients with cervical metastasis from squamous cell carcinoma of unknown primary (SCCUP) origin.METHODS: A systematic review including studies that encompassed palatine tonsillectomy in the SSCUP diagnostic evaluation was conducted. A single arm meta-analysis was then made to obtain the overall identification rate of tonsillectomy.RESULTS: Fourteen studies were included, comprising 673 patients who underwent 416 palatine tonsillectomies, 338 preformed during examination under anesthesia (EUA) and 78 managed with transoral robotic surgery (TORS). A total of 140 occult tonsillar malignancies were identified; of these, 124 (89%) were ipsilateral, 2 (1%) contralateral, and 14 (10%) synchronous bilateral. Meta-analysis of 11 studies showed an overall detection rate of tonsillectomy of 0.34 (99% confidence interval 0.23-0.46).CONCLUSION: Palatine tonsillectomy is a valuable diagnostic tool in the management of patients with head and neck SCCUP. Bilaterality of tonsillectomy should be taken into consideration.

U2 - 10.1002/hed.25522

DO - 10.1002/hed.25522

M3 - Review article

C2 - 30575162

SN - 1043-3074

VL - 41

SP - 1112

EP - 1121

JO - Head and Neck Surgery

JF - Head and Neck Surgery

IS - 4

ER -

Role of palatine tonsillectomy in the diagnostic workup of head and neck squamous cell carcinoma of unknown primary origin: A systematic review and meta-analysis

Abstract

Access to Document

Fingerprint

Cite this