Role of mTOR Signaling in Tumor Microenvironment: An Overview

F. Conciatori, C. Bazzichetto, I. Falcone, S. Pilotto, E. Bria, F. Cognetti, M. Milella, L. Ciuffreda

Research output: Contribution to journalArticlepeer-review


The mammalian target of rapamycin (mTOR) pathway regulates major processes by integrating a variety of exogenous cues, including diverse environmental inputs in the tumor microenvironment (TME). In recent years, it has been well recognized that cancer cells co-exist and co-evolve with their TME, which is often involved in drug resistance. The mTOR pathway modulates the interactions between the stroma and the tumor, thereby affecting both the tumor immunity and angiogenesis. The activation of mTOR signaling is associated with these pro-oncogenic cellular processes, making mTOR a promising target for new combination therapies. This review highlights the role of mTOR signaling in the characterization and the activity of the TME's elements and their implications in cancer immunotherapy.
Original languageEnglish
Pages (from-to)pii: E2453
JournalInternational Journal of Molecular Sciences
Issue number8
Publication statusPublished - Aug 19 2018


  • angiogenesis
  • immunotherapy
  • mTOR
  • tumor microenvironment


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