Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases

Amir Abbas Momtazi; Giuseppe Derosa; Pamela Maffioli; Maciej Banach; Amirhossein Sahebkar

doi:10.1007/s40291-016-0202-7

Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases

Amir Abbas Momtazi, Giuseppe Derosa, Pamela Maffioli, Maciej Banach, Amirhossein Sahebkar

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Review article › peer-review

Abstract

Curcumin is a bioactive polyphenol occurring in the rhizomes of Curcumalonga. It is well-reputed for its chemopreventive and anticancer properties; however, recent evidence has revealed numerous biological and pharmacological effects of curcumin that are relevant to the treatment of non-cancer diseases. Mechanistically, curcumin exerts its pharmacological effects through anti-inflammatory and antioxidant mechanisms via interaction with different signaling molecules and transcription factors. In addition, epigenetic modulators such as microRNAs (miRs) have emerged as novel targets of curcumin. Curcumin was found to modulate the expression of several pathogenic miRs in brain, ocular, renal, and liver diseases. The present systematic review was conducted to identify miRs that are regulated by curcumin in non-cancer diseases.

Original language	English
Pages (from-to)	335-345
Number of pages	11
Journal	Molecular Diagnosis and Therapy
Volume	20
Issue number	4
DOIs	https://doi.org/10.1007/s40291-016-0202-7
Publication status	Published - Aug 1 2016

ASJC Scopus subject areas

Genetics
Molecular Medicine
Medicine(all)
Pharmacology

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abstract = "Curcumin is a bioactive polyphenol occurring in the rhizomes of Curcumalonga. It is well-reputed for its chemopreventive and anticancer properties; however, recent evidence has revealed numerous biological and pharmacological effects of curcumin that are relevant to the treatment of non-cancer diseases. Mechanistically, curcumin exerts its pharmacological effects through anti-inflammatory and antioxidant mechanisms via interaction with different signaling molecules and transcription factors. In addition, epigenetic modulators such as microRNAs (miRs) have emerged as novel targets of curcumin. Curcumin was found to modulate the expression of several pathogenic miRs in brain, ocular, renal, and liver diseases. The present systematic review was conducted to identify miRs that are regulated by curcumin in non-cancer diseases.",

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AU - Maffioli, Pamela

AU - Banach, Maciej

AU - Sahebkar, Amirhossein

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AB - Curcumin is a bioactive polyphenol occurring in the rhizomes of Curcumalonga. It is well-reputed for its chemopreventive and anticancer properties; however, recent evidence has revealed numerous biological and pharmacological effects of curcumin that are relevant to the treatment of non-cancer diseases. Mechanistically, curcumin exerts its pharmacological effects through anti-inflammatory and antioxidant mechanisms via interaction with different signaling molecules and transcription factors. In addition, epigenetic modulators such as microRNAs (miRs) have emerged as novel targets of curcumin. Curcumin was found to modulate the expression of several pathogenic miRs in brain, ocular, renal, and liver diseases. The present systematic review was conducted to identify miRs that are regulated by curcumin in non-cancer diseases.

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Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases

Abstract

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