Role of IL-15 in immune-mediated and infectious diseases

Antonio Di Sabatino; Sandra A. Calarota; Francesca Vidali; Thomas T. MacDonald; Gino R. Corazza

doi:10.1016/j.cytogfr.2010.09.003

Role of IL-15 in immune-mediated and infectious diseases

Antonio Di Sabatino, Sandra A. Calarota, Francesca Vidali, Thomas T. MacDonald, Gino R. Corazza

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

IL-15 has a broad spectrum of biological activities. It is crucial for the development, proliferation, survival and differentiation of multiple cells from both innate and adaptive immune systems. However, IL-15 up-regulation has a central role in the development of several autoimmune or chronic inflammatory disorders. Therefore, targeting IL-15 or its receptor may have a valuable impact on the treatment of immune-mediated diseases. On the other hand, in some infectious diseases, IL-15 production is compromised but IL-15 given exogenously can potentially enhance immune responses to pathogens. Here, we discuss the current understanding of IL-15 role in immune-mediated and infectious diseases as well as its therapeutic use.

Original language	English
Pages (from-to)	19-33
Number of pages	15
Journal	Cytokine and Growth Factor Reviews
Volume	22
Issue number	1
DOIs	https://doi.org/10.1016/j.cytogfr.2010.09.003
Publication status	Published - Feb 2011

Keywords

Autoimmune diseases
IL-15
Immune system
Immune-therapeutic tool
Infectious diseases

ASJC Scopus subject areas

Immunology
Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cytogfr.2010.09.003

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title = "Role of IL-15 in immune-mediated and infectious diseases",

abstract = "IL-15 has a broad spectrum of biological activities. It is crucial for the development, proliferation, survival and differentiation of multiple cells from both innate and adaptive immune systems. However, IL-15 up-regulation has a central role in the development of several autoimmune or chronic inflammatory disorders. Therefore, targeting IL-15 or its receptor may have a valuable impact on the treatment of immune-mediated diseases. On the other hand, in some infectious diseases, IL-15 production is compromised but IL-15 given exogenously can potentially enhance immune responses to pathogens. Here, we discuss the current understanding of IL-15 role in immune-mediated and infectious diseases as well as its therapeutic use.",

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AU - Di Sabatino, Antonio

AU - Calarota, Sandra A.

AU - Vidali, Francesca

AU - MacDonald, Thomas T.

AU - Corazza, Gino R.

PY - 2011/2

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AB - IL-15 has a broad spectrum of biological activities. It is crucial for the development, proliferation, survival and differentiation of multiple cells from both innate and adaptive immune systems. However, IL-15 up-regulation has a central role in the development of several autoimmune or chronic inflammatory disorders. Therefore, targeting IL-15 or its receptor may have a valuable impact on the treatment of immune-mediated diseases. On the other hand, in some infectious diseases, IL-15 production is compromised but IL-15 given exogenously can potentially enhance immune responses to pathogens. Here, we discuss the current understanding of IL-15 role in immune-mediated and infectious diseases as well as its therapeutic use.

KW - Autoimmune diseases

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KW - Immune system

KW - Immune-therapeutic tool

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Role of IL-15 in immune-mediated and infectious diseases

Abstract

Keywords

ASJC Scopus subject areas

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