Role of DNA ploidy and ERB-B2 oncogene expression in the prognosis of endometrial carcinoma

F. Ferrara; L. De Santis; F. Mangili; I. Sassi; S. Luchini; C. Mandelli; G. Santambrogio; A. Cantaboni

Role of DNA ploidy and ERB-B2 oncogene expression in the prognosis of endometrial carcinoma

F. Ferrara, L. De Santis, F. Mangili, I. Sassi, S. Luchini, C. Mandelli, G. Santambrogio, A. Cantaboni

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Seventy-three patients with endometrial carcinoma have been retrospectively evaluated in this paper. Stage, grade, depth of myometrial invasion, flow cytometric DNA ploidy and ERB-B2 oncogene expression by immunohistochemical method have been analyzed on paraffin embedded tissue. Results showed the existence of a significant correlation between stage and grade of neoplasia and between DNA ploidy and course of disease; it has been observed that patients with aneuploid tumor tend to have a shorter time before relapse of disease. No significant correlation between depth of myometrial invasion and survival was found. Besides, it has been shown that tumours with ERB-B2 oncogene hyperexpression seem to have a more aggressive evolution.

Original language	English
Pages (from-to)	1039-1043
Number of pages	5
Journal	Pathology Research and Practice
Volume	190
Issue number	11
Publication status	Published - 1994

Keywords

DNA ploidy
Endometrial carcinoma
ERB-B2 overexpression
Immunohistochemistry
Oncogene

ASJC Scopus subject areas

Pathology and Forensic Medicine

Cite this

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title = "Role of DNA ploidy and ERB-B2 oncogene expression in the prognosis of endometrial carcinoma",

abstract = "Seventy-three patients with endometrial carcinoma have been retrospectively evaluated in this paper. Stage, grade, depth of myometrial invasion, flow cytometric DNA ploidy and ERB-B2 oncogene expression by immunohistochemical method have been analyzed on paraffin embedded tissue. Results showed the existence of a significant correlation between stage and grade of neoplasia and between DNA ploidy and course of disease; it has been observed that patients with aneuploid tumor tend to have a shorter time before relapse of disease. No significant correlation between depth of myometrial invasion and survival was found. Besides, it has been shown that tumours with ERB-B2 oncogene hyperexpression seem to have a more aggressive evolution.",

keywords = "DNA ploidy, Endometrial carcinoma, ERB-B2 overexpression, Immunohistochemistry, Oncogene",

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T1 - Role of DNA ploidy and ERB-B2 oncogene expression in the prognosis of endometrial carcinoma

AU - Ferrara, F.

AU - De Santis, L.

AU - Mangili, F.

AU - Sassi, I.

AU - Luchini, S.

AU - Mandelli, C.

AU - Santambrogio, G.

AU - Cantaboni, A.

PY - 1994

Y1 - 1994

N2 - Seventy-three patients with endometrial carcinoma have been retrospectively evaluated in this paper. Stage, grade, depth of myometrial invasion, flow cytometric DNA ploidy and ERB-B2 oncogene expression by immunohistochemical method have been analyzed on paraffin embedded tissue. Results showed the existence of a significant correlation between stage and grade of neoplasia and between DNA ploidy and course of disease; it has been observed that patients with aneuploid tumor tend to have a shorter time before relapse of disease. No significant correlation between depth of myometrial invasion and survival was found. Besides, it has been shown that tumours with ERB-B2 oncogene hyperexpression seem to have a more aggressive evolution.

AB - Seventy-three patients with endometrial carcinoma have been retrospectively evaluated in this paper. Stage, grade, depth of myometrial invasion, flow cytometric DNA ploidy and ERB-B2 oncogene expression by immunohistochemical method have been analyzed on paraffin embedded tissue. Results showed the existence of a significant correlation between stage and grade of neoplasia and between DNA ploidy and course of disease; it has been observed that patients with aneuploid tumor tend to have a shorter time before relapse of disease. No significant correlation between depth of myometrial invasion and survival was found. Besides, it has been shown that tumours with ERB-B2 oncogene hyperexpression seem to have a more aggressive evolution.

KW - DNA ploidy

KW - Endometrial carcinoma

KW - ERB-B2 overexpression

KW - Immunohistochemistry

KW - Oncogene

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Role of DNA ploidy and ERB-B2 oncogene expression in the prognosis of endometrial carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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