Role of dentate gyrus alterations in mesial temporal sclerosis

Gianluca Marucci, G. Rubboli, M. Giulioni

Research output: Contribution to journalArticlepeer-review


Drug-resistant chronic temporal lobe epilepsy is the most common type of epilepsy that undergoes surgical treatment. To verify if dentate gyrus alterations mayplay a role in patients with mesial temporal sclerosis (MTS), 14 patients, submitted to epilepsy surgery, were selected. Only cases with MTS alone were included. Granule cell dispersion (GCD) was observed in 7 cases (50%). A statistically significant correlation between GCD and the mean number of seizures/month was evidenced. The percentage of patients who did not achieve seizure relief (i.e. they were not in Engel class 1A) was 57.14% in patients without GCD, whereas that percentage dropped to 14.29% in patients with GCD. The association between a more favorable postsurgical epileptogenic outcome and granule cell pathology in patients with MTS has been observed, thus suggesting that dentate gyrus alterations may play a role in drug-resistant TLE.

Original languageEnglish
Pages (from-to)32-35
Number of pages4
JournalClinical Neuropathology
Issue number1
Publication statusPublished - 2010


  • Dentate gyrus
  • Epilepsy
  • Granular cell dispersion
  • Mesial temporal sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neurology


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