Role of DC-SIGN and L-SIGN receptors in HIV-1 vertical transmission

Ronaldo Celerino da Silva, Ludovica Segat, Sergio Crovella

Research output: Contribution to journalArticlepeer-review


The innate immune system acts in the first line of host defense against pathogens. One of the mechanisms used involves the early recognition and uptake of microbes by host professional phagocytes, through pattern recognition receptors (PRRs). These PRRs bind to conserved microbial ligands expressed by pathogens and initiate both innate and adaptative immune responses. Some PRRs located on the surface of dendritic cells (DCs) and other cells seem to play an important role in human immunodeficiency virus type 1 (HIV-1) transmission. Dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin, CD209 (DC-SIGN) and its homolog, DC-SIGN-related (DC-SIGNR or L-SIGN) receptors are PPRs able to bind the HIV-1 gp120 envelope protein and, because alterations in their expression patterns also occur, they might play a role in both horizontal and vertical transmission as well as in disseminating the virus within the host. This review aims to explore the involvement of the DC-SIGN and L-SIGN receptors in HIV-1 transmission from mother to child.

Original languageEnglish
Pages (from-to)305-311
Number of pages7
JournalHuman Immunology
Issue number4
Publication statusPublished - Apr 2011


  • HIV-1
  • L-SIGN
  • Vertical transmission

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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