Role of combined DWIBS/3D-CE-T1w whole-body MRI in tumor staging: Comparison with PET-CT

Guglielmo Manenti, Carmelo Cicciò, Ettore Squillaci, Lidia Strigari, Ferdinando Calabria, Roberta Danieli, Orazio Schillaci, Giovanni Simonetti

Research output: Contribution to journalArticlepeer-review


Objectives: To assess the diagnostic performance of whole-body magnetic resonance imaging (WB-MRI) by diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) in malignant tumor detection and the potential diagnostic advantages in generating fused DWIBS/3D-contrast enhanced T1w (3D-CE-T1w) images. Methods: 45 cancer patients underwent 18F-FDG PET-CT and WB-MRI for staging purpose. Fused DWIBS/3D-CE T1w images were generated off-line. 3D-CE-T1w, DWIBS images alone and fused with 3D-CE T1w were compared by two readers groups for detection of primary diseases and local/distant metastases. Diagnostic performance between the three WB-MRI data sets was assessed using receiver operating characteristic (ROC) curve analysis. Imaging exams and histopathological results were used as standard of references. Results: Areas under the ROC curves of DWIBS vs. 3D-CE-T1w vs. both sequences in fused fashion were 0.97, 0.978, and 1.00, respectively. The diagnostic performance in tumor detection of fused DWIBS/3D-CE-T1w images were statistically superior to DWIBS (p <0.001) and 3D-CE-T1w (p ≤ 0.002); while the difference between DWIBS and 3D-CE-T1w did not show statistical significance difference. Detection rates of malignancy did not differ between WB-MRI with DWIBS and 18F-FDG PET-CT. Conclusion: WB-MRI with DWIBS is to be considered as alternative tool to conventional whole-body methods for tumor staging and during follow-up in cancer patients.

Original languageEnglish
Pages (from-to)1917-1925
Number of pages9
JournalEuropean Journal of Radiology
Issue number8
Publication statusPublished - Aug 2012


  • Cancer staging
  • Diffusion weighted imaging (DWI)
  • Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS)
  • Positron emission tomography-computed tomography (PET-CT)
  • Whole-body magnetic resonance imaging (WB-MRI)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Role of combined DWIBS/3D-CE-T1w whole-body MRI in tumor staging: Comparison with PET-CT'. Together they form a unique fingerprint.

Cite this