Role of Citrate in Pathophysiology and Medical Management of Bone Diseases

Donatella Granchi; Nicola Baldini; Fabio Massimo Ulivieri; Renata Caudarella

doi:10.3390/nu11112576

Role of Citrate in Pathophysiology and Medical Management of Bone Diseases

Donatella Granchi, Nicola Baldini, Fabio Massimo Ulivieri, Renata Caudarella

Research output: Contribution to journal › Review article › peer-review

Abstract

Citrate is an intermediate in the "Tricarboxylic Acid Cycle" and is used by all aerobic organisms to produce usable chemical energy. It is a derivative of citric acid, a weak organic acid which can be introduced with diet since it naturally exists in a variety of fruits and vegetables, and can be consumed as a dietary supplement. The close association between this compound and bone was pointed out for the first time by Dickens in 1941, who showed that approximately 90% of the citrate bulk of the human body resides in mineralised tissues. Since then, the number of published articles has increased exponentially, and considerable progress in understanding how citrate is involved in bone metabolism has been made. This review summarises current knowledge regarding the role of citrate in the pathophysiology and medical management of bone disorders.

Original language	English
Pages (from-to)	1-30
Number of pages	30
Journal	Nutrients
Volume	11
Issue number	11
DOIs	https://doi.org/10.3390/nu11112576
Publication status	Published - Oct 25 2019

Keywords

bone metabolism
bone mineral density
bone remodelling
citrate supplement
osteopenia
osteoporosis
kidney diseases

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title = "Role of Citrate in Pathophysiology and Medical Management of Bone Diseases",

abstract = "Citrate is an intermediate in the {"}Tricarboxylic Acid Cycle{"} and is used by all aerobic organisms to produce usable chemical energy. It is a derivative of citric acid, a weak organic acid which can be introduced with diet since it naturally exists in a variety of fruits and vegetables, and can be consumed as a dietary supplement. The close association between this compound and bone was pointed out for the first time by Dickens in 1941, who showed that approximately 90% of the citrate bulk of the human body resides in mineralised tissues. Since then, the number of published articles has increased exponentially, and considerable progress in understanding how citrate is involved in bone metabolism has been made. This review summarises current knowledge regarding the role of citrate in the pathophysiology and medical management of bone disorders.",

keywords = "bone metabolism, bone mineral density, bone remodelling, citrate supplement, osteopenia, osteoporosis, kidney diseases",

author = "Donatella Granchi and Nicola Baldini and Ulivieri, {Fabio Massimo} and Renata Caudarella",

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doi = "10.3390/nu11112576",

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T1 - Role of Citrate in Pathophysiology and Medical Management of Bone Diseases

AU - Granchi, Donatella

AU - Baldini, Nicola

AU - Ulivieri, Fabio Massimo

AU - Caudarella, Renata

PY - 2019/10/25

Y1 - 2019/10/25

N2 - Citrate is an intermediate in the "Tricarboxylic Acid Cycle" and is used by all aerobic organisms to produce usable chemical energy. It is a derivative of citric acid, a weak organic acid which can be introduced with diet since it naturally exists in a variety of fruits and vegetables, and can be consumed as a dietary supplement. The close association between this compound and bone was pointed out for the first time by Dickens in 1941, who showed that approximately 90% of the citrate bulk of the human body resides in mineralised tissues. Since then, the number of published articles has increased exponentially, and considerable progress in understanding how citrate is involved in bone metabolism has been made. This review summarises current knowledge regarding the role of citrate in the pathophysiology and medical management of bone disorders.

AB - Citrate is an intermediate in the "Tricarboxylic Acid Cycle" and is used by all aerobic organisms to produce usable chemical energy. It is a derivative of citric acid, a weak organic acid which can be introduced with diet since it naturally exists in a variety of fruits and vegetables, and can be consumed as a dietary supplement. The close association between this compound and bone was pointed out for the first time by Dickens in 1941, who showed that approximately 90% of the citrate bulk of the human body resides in mineralised tissues. Since then, the number of published articles has increased exponentially, and considerable progress in understanding how citrate is involved in bone metabolism has been made. This review summarises current knowledge regarding the role of citrate in the pathophysiology and medical management of bone disorders.

KW - bone metabolism

KW - bone mineral density

KW - bone remodelling

KW - citrate supplement

KW - osteopenia

KW - osteoporosis

KW - kidney diseases

U2 - 10.3390/nu11112576

DO - 10.3390/nu11112576

M3 - Review article

C2 - 31731473

SN - 2072-6643

VL - 11

SP - 1

EP - 30

JO - Nutrients

JF - Nutrients

IS - 11

ER -

Role of Citrate in Pathophysiology and Medical Management of Bone Diseases

Abstract

Keywords

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