TY - JOUR
T1 - Role of cardiovascular risk factors (CRF) in the patients with mild cognitive impairment (MCI)
AU - Ettorre, E.
AU - Cerra, E.
AU - Marigliano, B.
AU - Vigliotta, M.
AU - Vulcano, A.
AU - Fossati, C.
AU - De Benedetto, G.
AU - Servello, A.
AU - Andreozzi, P.
AU - Marigliano, V.
PY - 2012/3
Y1 - 2012/3
N2 - Few therapeutic options are available nowadays to improve the prognosis of patients with Alzheimer's disease (AD). There are rather several evidences in literature that controlling vascular risk factors may be an effective intervention for modifying the course of this disease. The aim of our study was to investigate the role of CRF in 50 patients with MCI according to Petersens's criteria, and to evaluate their influence on cognitive and behavioral features of the disease and on the development of dementia. Statistical analysis of the data showed that the 60% of the patients with MCI and CRF developed dementia, while 40% maintained the same cognitive conditions at the end of the study. Only 32% of the subjects without cardiovascular comorbidities developed dementia. The results of the study suggest that CRF play a key role in cognitive decline of patients with MCI. Patients with MCI and CRF showed not only worse cognitive performances, but also behavioral disorders, depression and functional disability. Patients with CRF had higher conversion rate to AD than the other group, with a mean disease-free period 3 months shorter than the control group.
AB - Few therapeutic options are available nowadays to improve the prognosis of patients with Alzheimer's disease (AD). There are rather several evidences in literature that controlling vascular risk factors may be an effective intervention for modifying the course of this disease. The aim of our study was to investigate the role of CRF in 50 patients with MCI according to Petersens's criteria, and to evaluate their influence on cognitive and behavioral features of the disease and on the development of dementia. Statistical analysis of the data showed that the 60% of the patients with MCI and CRF developed dementia, while 40% maintained the same cognitive conditions at the end of the study. Only 32% of the subjects without cardiovascular comorbidities developed dementia. The results of the study suggest that CRF play a key role in cognitive decline of patients with MCI. Patients with MCI and CRF showed not only worse cognitive performances, but also behavioral disorders, depression and functional disability. Patients with CRF had higher conversion rate to AD than the other group, with a mean disease-free period 3 months shorter than the control group.
KW - Alzheimer's disease
KW - Cardiovascular risk factors
KW - Mild cognitive impairment
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U2 - 10.1016/j.archger.2011.04.025
DO - 10.1016/j.archger.2011.04.025
M3 - Article
C2 - 21632127
AN - SCOPUS:84857063538
SN - 0167-4943
VL - 54
SP - 330
EP - 332
JO - Archives of Gerontology and Geriatrics
JF - Archives of Gerontology and Geriatrics
IS - 2
ER -