Role of autophagy during methamphetamine neurotoxicity

Livia Pasquali, Gloria Lazzeri, Ciro Isidoro, Stefano Ruggieri, Antonio Paparelli, Francesco Fornai

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Methamphetamine causes nigrostriatal denervation and striatal dopamine loss, while sparing nigral cell bodies. Nigral dopamine neurons feature autophagic vacuoles and cytoplasmic α-synuclein-, ubiquitin- and parkin-positive inclusion-like bodies. On that basis, autophagy was considered essential in methamphetamine-induced neurotoxicity, but its neurotoxic or protective role has never been addressed. Here we review the gap between the descriptive evidence on activation of autophagy and the lack of knowledge about its role during methamphetamine intoxication. Our preliminary findings rule out a detrimental role for autophagy; this represents the first step in understanding the consequence of activation of autophagy in methamphetamine toxicity.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Number of pages6
Publication statusPublished - Oct 2008

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)00778923
ISSN (Electronic)17496632


  • Apoptosis
  • Dopamine
  • Methamphetamine
  • Neurodegeneration

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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