Risk factors for young-onset colorectal cancer

Valentina Rosato, Cristina Bosetti, Fabio Levi, Jerry Polesel, Antonella Zucchetto, Eva Negri, Carlo La Vecchia

Research output: Contribution to journalArticlepeer-review


Purpose: We investigated risk factors for colorectal cancer in early-onset cancers, to provide quantitative estimates for major selected risk factors. Methods: We analyzed data from three Italian and Swiss case-control studies conducted between 1985 and 2009, including 329 colorectal cancer cases and 1,361 controls aged ≤45 years. We computed odds ratios (ORs) from unconditional logistic regression models, adjusted for major confounding factors. Results: The OR of young-onset colorectal cancer was 4.50 for family history of colorectal cancer in first-degree relatives, the association being higher in subjects with affected siblings (OR 11.68) than parents (OR 3.75). The ORs of young-onset colorectal cancer were 1.56 for ≥14 drinks/week of alcohol, 1.56 for the highest tertile of processed meat, 0.40 for vegetables, 0.75 for fruit, and 0.78 for fish intake. Among micronutrients, the ORs were 0.52 for β-carotene, 0.68 for vitamin C, 0.38 for vitamin E, and 0.59 for folate. No significant associations emerged for physical activity, overweight, and diabetes. Conclusions: This study - the largest on young-onset colorectal cancer - confirms that several recognized risk factors for colorectal cancer are also relevant determinants of young-onset colorectal cancer. Family history of colorectal cancer in particular is a stronger risk factor in young subjects, as compared to middle age and elderly ones.

Original languageEnglish
Pages (from-to)335-341
Number of pages7
JournalCancer Causes and Control
Issue number2
Publication statusPublished - Feb 2013


  • Colorectal cancer
  • Family history
  • Foods
  • Nutrients
  • Risk factors
  • Young

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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