TY - JOUR
T1 - Rheumatoid arthritis and renal light-Chain deposition disease
T2 - Long-Term effectiveness of TNF-a blockade with etanercept
AU - Cavagna, Lorenzo
AU - Sepe, Vincenzo
AU - Bobbio-Pallavicini, Francesca
AU - Mangione, Filippo
AU - Caporali, Roberto
AU - Montecucco, Carlomaurizio
PY - 2011/9
Y1 - 2011/9
N2 - A 68-year-old woman diagnosed with erosive rheumatoid arthritis (RA) was treated with intramuscular methotrexate 15 mg weekly and oral prednisone 5 mg daily. A favorable outcome of 6 years was followed by RA flare and nephrotic syndrome (NS). Renal biopsy revealed non-amyloid light-chain deposition disease. Laboratory analysis and bone marrow biopsy excluded monoclonal protein and plasma cell dyscrasia. Addition of subcutaneous etanercept, 25 mg twice weekly allowed rapid control of both arthritis and NS. To date, after over 7-year follow-up, RA is in clinical remission, 24-h albuminuria is consistently below 0.5 g, and serum creatinine is 0.9 mg/dl.
AB - A 68-year-old woman diagnosed with erosive rheumatoid arthritis (RA) was treated with intramuscular methotrexate 15 mg weekly and oral prednisone 5 mg daily. A favorable outcome of 6 years was followed by RA flare and nephrotic syndrome (NS). Renal biopsy revealed non-amyloid light-chain deposition disease. Laboratory analysis and bone marrow biopsy excluded monoclonal protein and plasma cell dyscrasia. Addition of subcutaneous etanercept, 25 mg twice weekly allowed rapid control of both arthritis and NS. To date, after over 7-year follow-up, RA is in clinical remission, 24-h albuminuria is consistently below 0.5 g, and serum creatinine is 0.9 mg/dl.
KW - Etanercept
KW - Renal Light-Chain Deposition disease
KW - Rheumatoid arthritis
KW - TNF-blockade
KW - Tumor Necrosis Factor-alpha (TNF-alpha)
UR - http://www.scopus.com/inward/record.url?scp=80555133253&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80555133253&partnerID=8YFLogxK
U2 - 10.1007/s11255-010-9788-6
DO - 10.1007/s11255-010-9788-6
M3 - Article
C2 - 20559723
AN - SCOPUS:80555133253
SN - 0301-1623
VL - 43
SP - 909
EP - 912
JO - International Urology and Nephrology
JF - International Urology and Nephrology
IS - 3
ER -