Revised recommendations concerning palivizumab prophylaxis for respiratory syncytial virus (RSV)

Lina Bollani, Eugenio Baraldi, Gaetano Chirico, Andrea Dotta, Marcello Lanari, Antonello Del Vecchio, Paolo Manzoni, Antonio Boldrini, Piermichele Paolillo, Sandra Di Fabio, Luigi Orfeo, Mauro Stronati, Costantino Romagnoli

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Respiratory Syncytial Virus infections are one of the leading causes of severe respiratory diseases that require hospitalization and, in some cases, intensive care. Once resolved, there may be respiratory sequelae of varying severity. The lack of effective treatments for bronchiolitis and the lack of vaccines for RSV accentuate the role of prevention in decreasing the impact of this disease. Prevention of bronchiolitis strongly relies on the adoption of environment and the hygienic behavior measures; an additional prophylactic effect may be offered, in selected cases, by Palivizumab, a humanized monoclonal antibody produced by recombinant DNA technology, able to prevent RSV infection by blocking viral replication. After many years the Italian Society of Neonatology, on the basis of the most recent scientific knowledge, has decided to revise recommendations for the use of palivizumab in the prevention of RSV infection.

Original languageEnglish
Article number203
JournalItalian Journal of Pediatrics
Issue number1
Publication statusPublished - Dec 15 2015

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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