Reticulon protein-1C: A new hope in the treatment of different neuronal diseases

Federica Di Sano, Mauro Piacentini

Research output: Contribution to journalArticlepeer-review


Reticulons (RTNs) are a group of membrane proteins localized on the ER and known to regulate ER structure and functions. Several studies have suggested that RTNs are involved in different important cellular functions such as changes in calcium homeostasis, ER-stress-mediated cell death, and autophagy. RTNs have been demonstrated to exert a cancer specific proapoptotic function via the interaction or the modulation of specific proteins. Reticulons have also been implicated in different signaling pathways which are at the basis of the pathogenesis of several neurodegenerative diseases. In this paper we discuss the accumulating evidence identifying RTN-1C protein as a promising target in the treatment of different pathologies such as cancer or neurodegenerative disorders.

Original languageEnglish
Article number651805
JournalInternational Journal of Cell Biology
Publication statusPublished - 2012

ASJC Scopus subject areas

  • Cell Biology


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