Resveratrol as chemosensitizer agent: State of art and future perspectives

Veronica Cocetta, Vincenzo Quagliariello, Francesco Fiorica, Massimiliano Berretta, Monica Montopoli

Research output: Contribution to journalReview articlepeer-review


Resistance to chemotherapy still remains a major challenge in the clinic, impairing the quality of life and survival rate of patients. The identification of unconventional chemosensitizing agents is therefore an interesting aspect of cancer research. Resveratrol has emerged in the last decades as a fascinating molecule, able to modulate several cancer-related molecular mechanisms, suggesting a possible application as an adjuvant in cancer management. This review goes deep into the existing literature concerning the possible chemosensitizing effect of resveratrol associated with the most conventional chemotherapeutic drugs. Despite the promising effects observed in different cancer types in in vitro studies, the clinical translation still presents strong limitations due to the low bioavailability of resveratrol. Recently, efforts have been moved in the field of drug delivery to identifying possible strategies/formulations useful for a more effective administration. Despite the necessity of a huge implementation in this research area, resveratrol appears as a promising molecule able to sensitize resistant tumors to drugs, suggesting its potential use in therapy-refractory cancer patients.

Original languageEnglish
Article number2049
Pages (from-to)1-20
Number of pages20
JournalInternational Journal of Molecular Sciences
Issue number4
Publication statusPublished - Feb 2 2021


  • Cancer
  • Chemosensitization
  • Chemotherapy resistance
  • Drug resistance
  • Integrative medicine
  • Resveratrol

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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