Results of in vitro fertilization in Italy after the introduction of a new law

Paolo Emanuele Levi Setti, Elena Albani, Paola Novara, Amalia Cesana, Luciano Negri

Research output: Contribution to journalArticlepeer-review


Objective: To investigate the consequences of a law introduced in Italy in 2004 that forbids the fertilization or injection of more than three oocytes for assisted reproduction and does not allow any embryo selection or cryopreservation. Design: Retrospective observational analysis. Setting: Subfertile patients enrolled in an assisted reproduction program. Patient(s): Before the introduction of the law there were 1,179 cycles and after its enactment there were 1,860 cycles in 1,619 subfertile couples. Intervention(s): Ovarian stimulation for IVF/intracytoplasmic sperm injection (ICSI) attempts. Main Outcome Measure(s): Pregnancy and implantation rate. Result(s): Pregnancy rates (PR) per cycle (24.34% vs. 23.11%), per retrieval (28.64% vs. 25.65%), per transfer (31.37% vs. 27.74%), and the take-home babies per started cycle (19.1% vs. 18%) was not significantly different between the two periods. After introduction of the law, the PR significantly decreased in patients whose total motile sperm count was 6 (40.85% vs. 23.62%) and in patients receiving two embryos (35.71% vs. 23.53%). This difference was mostly the result of a reduced PR in patients

Original languageEnglish
Pages (from-to)1081-1086
Number of pages6
JournalFertility and Sterility
Issue number4
Publication statusPublished - Oct 2008


  • Assisted reproduction
  • law
  • legislation
  • pregnancy rate
  • reproductive migration

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine


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