Resting State Alpha Electroencephalographic Rhythms Are Affected by Sex in Cognitively Unimpaired Seniors and Patients with Alzheimer's Disease and Amnesic Mild Cognitive Impairment: A Retrospective and Exploratory Study

Claudio Babiloni; Giuseppe Noce; Raffaele Ferri; Roberta Lizio; Susanna Lopez; Ivan Lorenzo; Federico Tucci; Andrea Soricelli; Montserrat Zurrón; Fernando Díaz; Flavio Nobili; Dario Arnaldi; Francesco Famà; Carla Buttinelli; Franco Giubilei; Virginia Cipollini; Moira Marizzoni; Bahar Güntekin; Ebru Yıldırım; Lutfu Hanoğlu; Görsev Yener; Duygu Hünerli Gündüz; Paolo Onorati; Fabrizio Stocchi; Laura Vacca; Fernando Maestú; Giovanni B Frisoni; Claudio Del Percio

doi:10.1093/cercor/bhab348

Resting State Alpha Electroencephalographic Rhythms Are Affected by Sex in Cognitively Unimpaired Seniors and Patients with Alzheimer's Disease and Amnesic Mild Cognitive Impairment: A Retrospective and Exploratory Study

Claudio Babiloni, Giuseppe Noce, Raffaele Ferri, Roberta Lizio, Susanna Lopez, Ivan Lorenzo, Federico Tucci, Andrea Soricelli, Montserrat Zurrón, Fernando Díaz, Flavio Nobili, Dario Arnaldi, Francesco Famà, Carla Buttinelli, Franco Giubilei, Virginia Cipollini, Moira Marizzoni, Bahar Güntekin, Ebru Yıldırım, Lutfu HanoğluGörsev Yener, Duygu Hünerli Gündüz, Paolo Onorati, Fabrizio Stocchi, Laura Vacca, Fernando Maestú, Giovanni B Frisoni, Claudio Del Percio

Research output: Contribution to journal › Article › peer-review

Abstract

In the present retrospective and exploratory study, we tested the hypothesis that sex may affect cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms recorded in normal elderly (Nold) seniors and patients with Alzheimer's disease and mild cognitive impairment (ADMCI). Datasets in 69 ADMCI and 57 Nold individuals were taken from an international archive. The rsEEG rhythms were investigated at individual delta, theta, and alpha frequency bands and fixed beta (14-30 Hz) and gamma (30-40 Hz) bands. Each group was stratified into matched females and males. The sex factor affected the magnitude of rsEEG source activities in the Nold seniors. Compared with the males, the females were characterized by greater alpha source activities in all cortical regions. Similarly, the parietal, temporal, and occipital alpha source activities were greater in the ADMCI-females than the males. Notably, the present sex effects did not depend on core genetic (APOE4), neuropathological (Aβ42/phospho-tau ratio in the cerebrospinal fluid), structural neurodegenerative and cerebrovascular (MRI) variables characterizing sporadic AD-related processes in ADMCI seniors. These results suggest the sex factor may significantly affect neurophysiological brain neural oscillatory synchronization mechanisms underpinning the generation of dominant rsEEG alpha rhythms to regulate cortical arousal during quiet vigilance.

Original language	English
Journal	Cerebral cortex (New York, N.Y. : 1991)
DOIs	https://doi.org/10.1093/cercor/bhab348
Publication status	E-pub ahead of print - Oct 6 2021

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Babiloni, C., Noce, G., Ferri, R., Lizio, R., Lopez, S., Lorenzo, I., Tucci, F., Soricelli, A., Zurrón, M., Díaz, F., Nobili, F., Arnaldi, D., Famà, F., Buttinelli, C., Giubilei, F., Cipollini, V., Marizzoni, M., Güntekin, B., Yıldırım, E., ... Del Percio, C. (2021). Resting State Alpha Electroencephalographic Rhythms Are Affected by Sex in Cognitively Unimpaired Seniors and Patients with Alzheimer's Disease and Amnesic Mild Cognitive Impairment: A Retrospective and Exploratory Study. Cerebral cortex (New York, N.Y. : 1991). https://doi.org/10.1093/cercor/bhab348

Resting State Alpha Electroencephalographic Rhythms Are Affected by Sex in Cognitively Unimpaired Seniors and Patients with Alzheimer's Disease and Amnesic Mild Cognitive Impairment: A Retrospective and Exploratory Study. / Babiloni, Claudio; Noce, Giuseppe ; Ferri, Raffaele et al.

In: Cerebral cortex (New York, N.Y. : 1991), 06.10.2021.

Research output: Contribution to journal › Article › peer-review

Babiloni, C, Noce, G , Ferri, R , Lizio, R, Lopez, S, Lorenzo, I, Tucci, F, Soricelli, A, Zurrón, M, Díaz, F, Nobili, F , Arnaldi, D , Famà, F, Buttinelli, C, Giubilei, F, Cipollini, V, Marizzoni, M, Güntekin, B, Yıldırım, E, Hanoğlu, L, Yener, G, Gündüz, DH, Onorati, P, Stocchi, F , Vacca, L, Maestú, F, Frisoni, GB & Del Percio, C 2021, 'Resting State Alpha Electroencephalographic Rhythms Are Affected by Sex in Cognitively Unimpaired Seniors and Patients with Alzheimer's Disease and Amnesic Mild Cognitive Impairment: A Retrospective and Exploratory Study', Cerebral cortex (New York, N.Y. : 1991). https://doi.org/10.1093/cercor/bhab348

Babiloni C, Noce G , Ferri R , Lizio R, Lopez S, Lorenzo I et al. Resting State Alpha Electroencephalographic Rhythms Are Affected by Sex in Cognitively Unimpaired Seniors and Patients with Alzheimer's Disease and Amnesic Mild Cognitive Impairment: A Retrospective and Exploratory Study. Cerebral cortex (New York, N.Y. : 1991). 2021 Oct 6. Epub 2021 Oct 6. doi: 10.1093/cercor/bhab348

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title = "Resting State Alpha Electroencephalographic Rhythms Are Affected by Sex in Cognitively Unimpaired Seniors and Patients with Alzheimer's Disease and Amnesic Mild Cognitive Impairment: A Retrospective and Exploratory Study",

abstract = "In the present retrospective and exploratory study, we tested the hypothesis that sex may affect cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms recorded in normal elderly (Nold) seniors and patients with Alzheimer's disease and mild cognitive impairment (ADMCI). Datasets in 69 ADMCI and 57 Nold individuals were taken from an international archive. The rsEEG rhythms were investigated at individual delta, theta, and alpha frequency bands and fixed beta (14-30 Hz) and gamma (30-40 Hz) bands. Each group was stratified into matched females and males. The sex factor affected the magnitude of rsEEG source activities in the Nold seniors. Compared with the males, the females were characterized by greater alpha source activities in all cortical regions. Similarly, the parietal, temporal, and occipital alpha source activities were greater in the ADMCI-females than the males. Notably, the present sex effects did not depend on core genetic (APOE4), neuropathological (Aβ42/phospho-tau ratio in the cerebrospinal fluid), structural neurodegenerative and cerebrovascular (MRI) variables characterizing sporadic AD-related processes in ADMCI seniors. These results suggest the sex factor may significantly affect neurophysiological brain neural oscillatory synchronization mechanisms underpinning the generation of dominant rsEEG alpha rhythms to regulate cortical arousal during quiet vigilance.",

author = "Claudio Babiloni and Giuseppe Noce and Raffaele Ferri and Roberta Lizio and Susanna Lopez and Ivan Lorenzo and Federico Tucci and Andrea Soricelli and Montserrat Zurr{\'o}n and Fernando D{\'i}az and Flavio Nobili and Dario Arnaldi and Francesco Fam{\`a} and Carla Buttinelli and Franco Giubilei and Virginia Cipollini and Moira Marizzoni and Bahar G{\"u}ntekin and Ebru Yıldırım and Lutfu Hanoğlu and G{\"o}rsev Yener and G{\"u}nd{\"u}z, {Duygu H{\"u}nerli} and Paolo Onorati and Fabrizio Stocchi and Laura Vacca and Fernando Maest{\'u} and Frisoni, {Giovanni B} and {Del Percio}, Claudio",

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T1 - Resting State Alpha Electroencephalographic Rhythms Are Affected by Sex in Cognitively Unimpaired Seniors and Patients with Alzheimer's Disease and Amnesic Mild Cognitive Impairment: A Retrospective and Exploratory Study

AU - Babiloni, Claudio

AU - Noce, Giuseppe

AU - Ferri, Raffaele

AU - Lizio, Roberta

AU - Lopez, Susanna

AU - Lorenzo, Ivan

AU - Tucci, Federico

AU - Soricelli, Andrea

AU - Zurrón, Montserrat

AU - Díaz, Fernando

AU - Nobili, Flavio

AU - Arnaldi, Dario

AU - Famà, Francesco

AU - Buttinelli, Carla

AU - Giubilei, Franco

AU - Cipollini, Virginia

AU - Marizzoni, Moira

AU - Güntekin, Bahar

AU - Yıldırım, Ebru

AU - Hanoğlu, Lutfu

AU - Yener, Görsev

AU - Gündüz, Duygu Hünerli

AU - Onorati, Paolo

AU - Stocchi, Fabrizio

AU - Vacca, Laura

AU - Maestú, Fernando

AU - Frisoni, Giovanni B

AU - Del Percio, Claudio

PY - 2021/10/6

Y1 - 2021/10/6

N2 - In the present retrospective and exploratory study, we tested the hypothesis that sex may affect cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms recorded in normal elderly (Nold) seniors and patients with Alzheimer's disease and mild cognitive impairment (ADMCI). Datasets in 69 ADMCI and 57 Nold individuals were taken from an international archive. The rsEEG rhythms were investigated at individual delta, theta, and alpha frequency bands and fixed beta (14-30 Hz) and gamma (30-40 Hz) bands. Each group was stratified into matched females and males. The sex factor affected the magnitude of rsEEG source activities in the Nold seniors. Compared with the males, the females were characterized by greater alpha source activities in all cortical regions. Similarly, the parietal, temporal, and occipital alpha source activities were greater in the ADMCI-females than the males. Notably, the present sex effects did not depend on core genetic (APOE4), neuropathological (Aβ42/phospho-tau ratio in the cerebrospinal fluid), structural neurodegenerative and cerebrovascular (MRI) variables characterizing sporadic AD-related processes in ADMCI seniors. These results suggest the sex factor may significantly affect neurophysiological brain neural oscillatory synchronization mechanisms underpinning the generation of dominant rsEEG alpha rhythms to regulate cortical arousal during quiet vigilance.

AB - In the present retrospective and exploratory study, we tested the hypothesis that sex may affect cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms recorded in normal elderly (Nold) seniors and patients with Alzheimer's disease and mild cognitive impairment (ADMCI). Datasets in 69 ADMCI and 57 Nold individuals were taken from an international archive. The rsEEG rhythms were investigated at individual delta, theta, and alpha frequency bands and fixed beta (14-30 Hz) and gamma (30-40 Hz) bands. Each group was stratified into matched females and males. The sex factor affected the magnitude of rsEEG source activities in the Nold seniors. Compared with the males, the females were characterized by greater alpha source activities in all cortical regions. Similarly, the parietal, temporal, and occipital alpha source activities were greater in the ADMCI-females than the males. Notably, the present sex effects did not depend on core genetic (APOE4), neuropathological (Aβ42/phospho-tau ratio in the cerebrospinal fluid), structural neurodegenerative and cerebrovascular (MRI) variables characterizing sporadic AD-related processes in ADMCI seniors. These results suggest the sex factor may significantly affect neurophysiological brain neural oscillatory synchronization mechanisms underpinning the generation of dominant rsEEG alpha rhythms to regulate cortical arousal during quiet vigilance.

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DO - 10.1093/cercor/bhab348

M3 - Article

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SN - 1047-3211

JO - Cerebral Cortex

JF - Cerebral Cortex

ER -