Reproductive factors and risk of uterine fibroids

Fabio Parazzini, Eva Negri, Carlo La Vecchia, Liliane Chatenoud, Elena Ricci, Paolo Guarnerio

Research output: Contribution to journalArticlepeer-review


We analyzed the relation between reproductive history and risk of uterine fibroids rising data from a case-control study. Cases were 621 women with histologically confirmed diagnosis of uterine fibroids. Controls were 1,051 nonhysterectomized patients. Compared with nulliparae, parous women had a relative risk (RR) of fibroids of 0.5 [95% confidence interval (CI) = 0.4- 0.6], and the risk declined with number of births. The risk of fibroids also decreased with number of induced abortions (RR = 0.8 and 0.6 for women reporting one or two or more abortions, respectively). A total of 24 cases (3.9%) and 19 controls (1.8%) reported a history of infertility (RR = 2.0; 95% CI = 1.1-3.7).

Original languageEnglish
Pages (from-to)440-442
Number of pages3
Issue number4
Publication statusPublished - 1996


  • reproductive factors
  • risk factors
  • uterine leiomyomas

ASJC Scopus subject areas

  • Epidemiology


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