Repeated immune and non immune insults to the graft after heart transplantation

Valeria Crudele; Antonietta Picascia; Teresa Infante; Vincenzo Grimaldi; Ciro Maiello; Claudio Napoli

doi:10.1016/j.imlet.2011.07.004

Repeated immune and non immune insults to the graft after heart transplantation

Valeria Crudele, Antonietta Picascia, Teresa Infante, Vincenzo Grimaldi, Ciro Maiello, Claudio Napoli

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Research output: Contribution to journal › Article › peer-review

Abstract

The clinical transplantation outcome is related to both effects of immunological and non immunological factors degenerating into hyperacute, acute and chronic rejection. Modern immunosuppressive treatments have resolved most events linked to acute rejection while long-term survival still remains the major problem after heart transplantation. The goal of personalized immunosuppressive therapy is to prevent rejection without inducing toxic effects. The aim of future studies could be to clarify the pathogenesis of chronic rejection and develop new and less toxic therapeutic approaches to induce "tolerance" to the graft without major side effects.

Original language	English
Pages (from-to)	18-27
Number of pages	10
Journal	Immunology Letters
Volume	141
Issue number	1
DOIs	https://doi.org/10.1016/j.imlet.2011.07.004
Publication status	Published - Dec 30 2011

Keywords

Acute and chronic rejection
Cardiac Allograft Vasculopathy (CAV)
Heart transplantation
Immunosuppressive therapy

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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10.1016/j.imlet.2011.07.004

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AU - Crudele, Valeria

AU - Picascia, Antonietta

AU - Infante, Teresa

AU - Grimaldi, Vincenzo

AU - Maiello, Ciro

AU - Napoli, Claudio

PY - 2011/12/30

Y1 - 2011/12/30

N2 - The clinical transplantation outcome is related to both effects of immunological and non immunological factors degenerating into hyperacute, acute and chronic rejection. Modern immunosuppressive treatments have resolved most events linked to acute rejection while long-term survival still remains the major problem after heart transplantation. The goal of personalized immunosuppressive therapy is to prevent rejection without inducing toxic effects. The aim of future studies could be to clarify the pathogenesis of chronic rejection and develop new and less toxic therapeutic approaches to induce "tolerance" to the graft without major side effects.

AB - The clinical transplantation outcome is related to both effects of immunological and non immunological factors degenerating into hyperacute, acute and chronic rejection. Modern immunosuppressive treatments have resolved most events linked to acute rejection while long-term survival still remains the major problem after heart transplantation. The goal of personalized immunosuppressive therapy is to prevent rejection without inducing toxic effects. The aim of future studies could be to clarify the pathogenesis of chronic rejection and develop new and less toxic therapeutic approaches to induce "tolerance" to the graft without major side effects.

KW - Acute and chronic rejection

KW - Cardiac Allograft Vasculopathy (CAV)

KW - Heart transplantation

KW - Immunosuppressive therapy

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Repeated immune and non immune insults to the graft after heart transplantation

Abstract

Keywords

ASJC Scopus subject areas

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