Repeated calcitonin treatment reduces the stimulation of inositol phospholipid by norepinephrine and serotonin in rat hippocampus and cerebral cortex

Giuseppe Clementi; Antonella Favit; Roberto Curreri; Ferdinando Nicoletti; Umberto Scapagnini

doi:10.1016/0006-8993(89)91485-6

Repeated calcitonin treatment reduces the stimulation of inositol phospholipid by norepinephrine and serotonin in rat hippocampus and cerebral cortex

Giuseppe Clementi, Antonella Favit, Roberto Curreri, Ferdinando Nicoletti, Umberto Scapagnini

www.neuromed.it

Research output: Contribution to journal › Article › peer-review

Abstract

Stimulation of inositol phospholipid hydrolysis by norepinephrine or 5-hydroxytryptamine was reduced in hippocampal or cortical slices from rats repeatedly injected with (Asu^1.7)eel-calcitonin (2.5 IU/kg i.p.). This effect was specific, as the basal or c carbamylcholine-stimulated inositol phospholipi hydrolysis was unchanged in slices from calcitonin-injected animals. The reduced responsiveness to norepinephrine did not reflect a decreased number or affinity of α₁-adrenergic recognition sites, suggesting that calcitonin treatment leads to a reduced coupling between α₁-adrenoreceptors and phospholipase C.

Original language	English
Pages (from-to)	138-142
Number of pages	5
Journal	Brain Research
Volume	478
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(89)91485-6
Publication status	Published - Jan 23 1989

Keywords

(Asu)eel-calcitonin
Cortex
Cyclic adenosine monophosphate
Hippocampus
Inositol phospholipid
Norepinephrine
Serotonin

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

Access to Document

10.1016/0006-8993(89)91485-6

Cite this

@article{d22ef4313360474c9fbd17810b5351db,

title = "Repeated calcitonin treatment reduces the stimulation of inositol phospholipid by norepinephrine and serotonin in rat hippocampus and cerebral cortex",

abstract = "Stimulation of inositol phospholipid hydrolysis by norepinephrine or 5-hydroxytryptamine was reduced in hippocampal or cortical slices from rats repeatedly injected with (Asu1.7)eel-calcitonin (2.5 IU/kg i.p.). This effect was specific, as the basal or c carbamylcholine-stimulated inositol phospholipi hydrolysis was unchanged in slices from calcitonin-injected animals. The reduced responsiveness to norepinephrine did not reflect a decreased number or affinity of α1-adrenergic recognition sites, suggesting that calcitonin treatment leads to a reduced coupling between α1-adrenoreceptors and phospholipase C.",

keywords = "(Asu)eel-calcitonin, Cortex, Cyclic adenosine monophosphate, Hippocampus, Inositol phospholipid, Norepinephrine, Serotonin",

author = "Giuseppe Clementi and Antonella Favit and Roberto Curreri and Ferdinando Nicoletti and Umberto Scapagnini",

year = "1989",

month = jan,

day = "23",

doi = "10.1016/0006-8993(89)91485-6",

language = "English",

volume = "478",

pages = "138--142",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Repeated calcitonin treatment reduces the stimulation of inositol phospholipid by norepinephrine and serotonin in rat hippocampus and cerebral cortex

AU - Clementi, Giuseppe

AU - Favit, Antonella

AU - Curreri, Roberto

AU - Nicoletti, Ferdinando

AU - Scapagnini, Umberto

PY - 1989/1/23

Y1 - 1989/1/23

N2 - Stimulation of inositol phospholipid hydrolysis by norepinephrine or 5-hydroxytryptamine was reduced in hippocampal or cortical slices from rats repeatedly injected with (Asu1.7)eel-calcitonin (2.5 IU/kg i.p.). This effect was specific, as the basal or c carbamylcholine-stimulated inositol phospholipi hydrolysis was unchanged in slices from calcitonin-injected animals. The reduced responsiveness to norepinephrine did not reflect a decreased number or affinity of α1-adrenergic recognition sites, suggesting that calcitonin treatment leads to a reduced coupling between α1-adrenoreceptors and phospholipase C.

AB - Stimulation of inositol phospholipid hydrolysis by norepinephrine or 5-hydroxytryptamine was reduced in hippocampal or cortical slices from rats repeatedly injected with (Asu1.7)eel-calcitonin (2.5 IU/kg i.p.). This effect was specific, as the basal or c carbamylcholine-stimulated inositol phospholipi hydrolysis was unchanged in slices from calcitonin-injected animals. The reduced responsiveness to norepinephrine did not reflect a decreased number or affinity of α1-adrenergic recognition sites, suggesting that calcitonin treatment leads to a reduced coupling between α1-adrenoreceptors and phospholipase C.

KW - (Asu)eel-calcitonin

KW - Cortex

KW - Cyclic adenosine monophosphate

KW - Hippocampus

KW - Inositol phospholipid

KW - Norepinephrine

KW - Serotonin

UR - http://www.scopus.com/inward/record.url?scp=0024578691&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024578691&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(89)91485-6

DO - 10.1016/0006-8993(89)91485-6

M3 - Article

C2 - 2924109

AN - SCOPUS:0024578691

SN - 0006-8993

VL - 478

SP - 138

EP - 142

JO - Brain Research

JF - Brain Research

IS - 1

ER -

Repeated calcitonin treatment reduces the stimulation of inositol phospholipid by norepinephrine and serotonin in rat hippocampus and cerebral cortex

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this