TY - CHAP
T1 - Renal transplantation
T2 - Strategies to prevent organ rejection - The role of an Inter-Regional Reference Center
AU - Cardillo, Massimo
AU - Poli, Francesca
AU - Barraco, Fiorenza
AU - De Fazio, Nicola
AU - Rossini, Giuseppe
AU - Boschiero, Luigi
AU - Nocera, Arcangelo
AU - Rigotti, Paolo
AU - Marchini, Francesco
AU - Zacchello, Graziella
AU - Zanon, Gianfranco
AU - Sandrini, Silvio
AU - Chiaramonte, Stefano
AU - Maresca, Cristina
AU - Caldara, Rossana
AU - Messa, Piergiorgio
AU - Berardinelli, Luisa
AU - Ambrosini, Andrea
AU - Montanaro, Domenico
AU - Rampino, Teresa
AU - Minetti, Enrico
AU - Gotti, Eliana
AU - Ghio, Luciana
AU - Ginevri, Fabrizio
AU - Albertario, Fulvio
AU - Scalamogna, Mario
PY - 2005
Y1 - 2005
N2 - This paper summarizes the role of the Inter-Regional Reference Center (RC) of the North Italy Transplant program (NITp), in coordinating a donor procurement and organ transplantation network, with a special focus on the strategies to minimize immunological risk and complications after transplantation. In the NITp, patients enrolled on the renal transplantation (RT) waiting list are typed for HLA-A,B,DRB1 antigens with a genomic method. They are periodically screened for the presence of lymphocytotoxic antibodies in their serum by the RC and their suitability to receive the transplant is checked periodically. Cadaver kidney allocation is ruled by a computerized algorithm, named NITK3, established in 1997, which aims at ensuring quality, equity, transparency and traceability during all the phases of the allocation decision-making process. NITK3 has been set up by the NITp Working Group on the basis of biological, medical and administrative criteria and it is periodically reviewed after the analysis of transplant results. In this paper, we show the results of a preliminary analysis of RTs performed from 1998 to 2002 in nine out of sixteen centers of the NITp area, which demonstrates the general quality of the NITp program in terms of patients and graft survival and the special attention to the patients at higher immunological risk.
AB - This paper summarizes the role of the Inter-Regional Reference Center (RC) of the North Italy Transplant program (NITp), in coordinating a donor procurement and organ transplantation network, with a special focus on the strategies to minimize immunological risk and complications after transplantation. In the NITp, patients enrolled on the renal transplantation (RT) waiting list are typed for HLA-A,B,DRB1 antigens with a genomic method. They are periodically screened for the presence of lymphocytotoxic antibodies in their serum by the RC and their suitability to receive the transplant is checked periodically. Cadaver kidney allocation is ruled by a computerized algorithm, named NITK3, established in 1997, which aims at ensuring quality, equity, transparency and traceability during all the phases of the allocation decision-making process. NITK3 has been set up by the NITp Working Group on the basis of biological, medical and administrative criteria and it is periodically reviewed after the analysis of transplant results. In this paper, we show the results of a preliminary analysis of RTs performed from 1998 to 2002 in nine out of sixteen centers of the NITp area, which demonstrates the general quality of the NITp program in terms of patients and graft survival and the special attention to the patients at higher immunological risk.
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M3 - Chapter
C2 - 15567915
AN - SCOPUS:16544383454
SN - 3805578563
SN - 9783805578561
VL - 146
T3 - Contributions to Nephrology
SP - 1
EP - 10
BT - Contributions to Nephrology
ER -