TY - JOUR
T1 - Relationship between vitamin D status and left ventricular geometry in a healthy population
T2 - Results from the Baltimore Longitudinal Study of Aging
AU - Ameri, P.
AU - Canepa, M.
AU - Milaneschi, Y.
AU - Spallarossa, P.
AU - Leoncini, G.
AU - Giallauria, F.
AU - Strait, J. B.
AU - Lakatta, E. G.
AU - Brunelli, C.
AU - Murialdo, G.
AU - Ferrucci, L.
PY - 2013/3
Y1 - 2013/3
N2 - Objectives: The effects of vitamin D on the heart have been studied in patients with cardiac disease, but not in healthy persons. We investigated the relation between vitamin D status and left ventricular (LV) structure and function in community-dwelling subjects without heart disease. Design: The relationship between concentrations of 25-hydroxyvitamin D [25(OH)D], a marker of vitamin D reserve, and LV transthoracic echocardiography measures was analysed in 711 participants in the Baltimore Longitudinal Study of Aging who were without cardiac disease. Results: Mean 25(OH)D in the study population was 32.3 ± 11.4 ng mL-1; only 15.5% of subjects had moderate or severe vitamin D deficiency [25(OH)D -1]. Adjusting for age, body mass index, cardiovascular disease risk factors, physical activity, calcium and parathyroid hormone, 25(OH)D was positively correlated with LV thickness (β 0.095, SE 0.039, P -1 [odds ratio (OR) 1.24; 95% confidence interval (CI) 0.83-1.85] or ≥38 ng mL-1 (OR 1.73; 95% CI 1.13-2.65), compared with those with 30-37 ng mL-1 25(OH)D. Consistently, LV relative wall thickness was significantly lower (P for trend=0.05), and LV diastolic internal diameter index (P for trend-1 25(OH)D compared to the rest of the study population. There was a significant interaction between 25(OH)D and hypertension on the risk of LV hypertrophy (P
AB - Objectives: The effects of vitamin D on the heart have been studied in patients with cardiac disease, but not in healthy persons. We investigated the relation between vitamin D status and left ventricular (LV) structure and function in community-dwelling subjects without heart disease. Design: The relationship between concentrations of 25-hydroxyvitamin D [25(OH)D], a marker of vitamin D reserve, and LV transthoracic echocardiography measures was analysed in 711 participants in the Baltimore Longitudinal Study of Aging who were without cardiac disease. Results: Mean 25(OH)D in the study population was 32.3 ± 11.4 ng mL-1; only 15.5% of subjects had moderate or severe vitamin D deficiency [25(OH)D -1]. Adjusting for age, body mass index, cardiovascular disease risk factors, physical activity, calcium and parathyroid hormone, 25(OH)D was positively correlated with LV thickness (β 0.095, SE 0.039, P -1 [odds ratio (OR) 1.24; 95% confidence interval (CI) 0.83-1.85] or ≥38 ng mL-1 (OR 1.73; 95% CI 1.13-2.65), compared with those with 30-37 ng mL-1 25(OH)D. Consistently, LV relative wall thickness was significantly lower (P for trend=0.05), and LV diastolic internal diameter index (P for trend-1 25(OH)D compared to the rest of the study population. There was a significant interaction between 25(OH)D and hypertension on the risk of LV hypertrophy (P
KW - Heart
KW - Left ventricular mass
KW - Left ventricular remodelling
KW - Population
KW - Vitamin D
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U2 - 10.1111/joim.12007
DO - 10.1111/joim.12007
M3 - Article
C2 - 23061475
AN - SCOPUS:84873985785
SN - 0954-6820
VL - 273
SP - 253
EP - 262
JO - Journal of Internal Medicine
JF - Journal of Internal Medicine
IS - 3
ER -