Relationship between motor function of the proximal stomach and transient lower oesophageal sphincter relaxation after morphine

R. Penagini; M. Allocca; P. Cantù; M. Mangano; D. Savojardo; S. Carmagnola; P. A. Bianchi

doi:10.1136/gut.2003.035246

Relationship between motor function of the proximal stomach and transient lower oesophageal sphincter relaxation after morphine

R. Penagini, M. Allocca, P. Cantù, M. Mangano, D. Savojardo, S. Carmagnola, P. A. Bianchi

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Morphine reduces the rate of transient lower oesophageal sphincter (LOS) relaxations but its site of action is presently unknown. There are no data available concerning its motor effects on the proximal stomach, an important site for triggering transient LOS relaxations. Aim: To evaluate the effect of morphine on the rate of transient LOS relaxations and motor function of the proximal stomach. Subjects and methods: In 19 healthy subjects, concurrent transient LOS relaxations with a sleeve sensor and motor function of the proximal stomach with a bag connected to an electronic barostat were recorded during pressure controlled (n = 9) and volume controlled (n = 10) gastric distensions after intravenous administration of placebo and morphine 100 μg/kg. Results: During pressure controlled distensions, intrabag volume was markedly decreased by morphine (median 189 ml (interquartile range 101-448) v 404 (265-868) after placebo; p

Original language	English
Pages (from-to)	1227-1231
Number of pages	5
Journal	Gut
Volume	53
Issue number	9
DOIs	https://doi.org/10.1136/gut.2003.035246
Publication status	Published - Sept 2004

ASJC Scopus subject areas

Gastroenterology

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10.1136/gut.2003.035246

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title = "Relationship between motor function of the proximal stomach and transient lower oesophageal sphincter relaxation after morphine",

abstract = "Background: Morphine reduces the rate of transient lower oesophageal sphincter (LOS) relaxations but its site of action is presently unknown. There are no data available concerning its motor effects on the proximal stomach, an important site for triggering transient LOS relaxations. Aim: To evaluate the effect of morphine on the rate of transient LOS relaxations and motor function of the proximal stomach. Subjects and methods: In 19 healthy subjects, concurrent transient LOS relaxations with a sleeve sensor and motor function of the proximal stomach with a bag connected to an electronic barostat were recorded during pressure controlled (n = 9) and volume controlled (n = 10) gastric distensions after intravenous administration of placebo and morphine 100 μg/kg. Results: During pressure controlled distensions, intrabag volume was markedly decreased by morphine (median 189 ml (interquartile range 101-448) v 404 (265-868) after placebo; p",

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T1 - Relationship between motor function of the proximal stomach and transient lower oesophageal sphincter relaxation after morphine

AU - Penagini, R.

AU - Allocca, M.

AU - Cantù, P.

AU - Mangano, M.

AU - Savojardo, D.

AU - Carmagnola, S.

AU - Bianchi, P. A.

PY - 2004/9

Y1 - 2004/9

N2 - Background: Morphine reduces the rate of transient lower oesophageal sphincter (LOS) relaxations but its site of action is presently unknown. There are no data available concerning its motor effects on the proximal stomach, an important site for triggering transient LOS relaxations. Aim: To evaluate the effect of morphine on the rate of transient LOS relaxations and motor function of the proximal stomach. Subjects and methods: In 19 healthy subjects, concurrent transient LOS relaxations with a sleeve sensor and motor function of the proximal stomach with a bag connected to an electronic barostat were recorded during pressure controlled (n = 9) and volume controlled (n = 10) gastric distensions after intravenous administration of placebo and morphine 100 μg/kg. Results: During pressure controlled distensions, intrabag volume was markedly decreased by morphine (median 189 ml (interquartile range 101-448) v 404 (265-868) after placebo; p

AB - Background: Morphine reduces the rate of transient lower oesophageal sphincter (LOS) relaxations but its site of action is presently unknown. There are no data available concerning its motor effects on the proximal stomach, an important site for triggering transient LOS relaxations. Aim: To evaluate the effect of morphine on the rate of transient LOS relaxations and motor function of the proximal stomach. Subjects and methods: In 19 healthy subjects, concurrent transient LOS relaxations with a sleeve sensor and motor function of the proximal stomach with a bag connected to an electronic barostat were recorded during pressure controlled (n = 9) and volume controlled (n = 10) gastric distensions after intravenous administration of placebo and morphine 100 μg/kg. Results: During pressure controlled distensions, intrabag volume was markedly decreased by morphine (median 189 ml (interquartile range 101-448) v 404 (265-868) after placebo; p

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Relationship between motor function of the proximal stomach and transient lower oesophageal sphincter relaxation after morphine

Abstract

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