Relation of cathepsin D level to the estrogen receptor in human breast cancer

Santo Marsigliante; Luciana Biscozzo; Simona Greco; Giuseppe Leo; Carlo Storelli

doi:10.1007/BF02591395

Relation of cathepsin D level to the estrogen receptor in human breast cancer

Santo Marsigliante, Luciana Biscozzo, Simona Greco, Giuseppe Leo, Carlo Storelli

IRCCS Policlinico San Donato

Research output: Contribution to journal › Article › peer-review

Abstract

Seventy-three primary human breast cancers were analyzed to assess the presence of estrogen and progesterone receptors, the p29 protein, and the total cathepsin D status. No significant relationship was found between cathepsin D concentration and the presence of ER or PR, either by Fisher's exact test or Spearman's rank correlation (P>0.1). However, a significant association was found between cathepsin D and p29 (Fisher's exact test, P0.05). Steroid receptors and cathepsin D were also assayed in samples of non-malignant tissue from 16 mastectomies; there was a significantly higher relative concentration of cathepsin D in the malignant specimens (Stundent's t-test, P

Original language	English
Pages (from-to)	52-57
Number of pages	6
Journal	International Journal of Clinical & Laboratory Research
Volume	22
Issue number	1-4
DOIs	https://doi.org/10.1007/BF02591395
Publication status	Published - Mar 1992

Keywords

Breast cancer
Cathepsin D
Estrogen receptor
p29
Progesterone receptor

ASJC Scopus subject areas

Clinical Biochemistry

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10.1007/BF02591395

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AU - Marsigliante, Santo

AU - Biscozzo, Luciana

AU - Greco, Simona

AU - Leo, Giuseppe

AU - Storelli, Carlo

PY - 1992/3

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AB - Seventy-three primary human breast cancers were analyzed to assess the presence of estrogen and progesterone receptors, the p29 protein, and the total cathepsin D status. No significant relationship was found between cathepsin D concentration and the presence of ER or PR, either by Fisher's exact test or Spearman's rank correlation (P>0.1). However, a significant association was found between cathepsin D and p29 (Fisher's exact test, P0.05). Steroid receptors and cathepsin D were also assayed in samples of non-malignant tissue from 16 mastectomies; there was a significantly higher relative concentration of cathepsin D in the malignant specimens (Stundent's t-test, P

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Relation of cathepsin D level to the estrogen receptor in human breast cancer

Abstract

Keywords

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