Relation of cathepsin D level to the estrogen receptor in human breast cancer

Santo Marsigliante, Luciana Biscozzo, Simona Greco, Giuseppe Leo, Carlo Storelli

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Seventy-three primary human breast cancers were analyzed to assess the presence of estrogen and progesterone receptors, the p29 protein, and the total cathepsin D status. No significant relationship was found between cathepsin D concentration and the presence of ER or PR, either by Fisher's exact test or Spearman's rank correlation (P>0.1). However, a significant association was found between cathepsin D and p29 (Fisher's exact test, P0.05). Steroid receptors and cathepsin D were also assayed in samples of non-malignant tissue from 16 mastectomies; there was a significantly higher relative concentration of cathepsin D in the malignant specimens (Stundent's t-test, P

Original languageEnglish
Pages (from-to)52-57
Number of pages6
JournalInternational Journal of Clinical & Laboratory Research
Issue number1-4
Publication statusPublished - Mar 1992


  • Breast cancer
  • Cathepsin D
  • Estrogen receptor
  • p29
  • Progesterone receptor

ASJC Scopus subject areas

  • Clinical Biochemistry


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