Regulatory CD4 T cells: sensing the environment

Giuseppe Matarese, Veronica De Rosa, Antonio La Cava

Research output: Contribution to journalArticlepeer-review


The immunosuppressive properties of naturally occurring regulatory T cells (Tregs) have classically been linked to an intrinsic state of hyporesponsiveness, yet, paradoxically, Tregs are phenotypically in an activated state and have intact proliferative capacity. In consideration of several recent biochemical reports on the intracellular signaling pathways operating in activated CD4+CD25+ Tregs, we argue that the responsiveness of Tregs depends greatly on the local microenvironment. In particular, what influences Tregs to remain anergic or to proliferate arises from their ability to probe the extracellular milieu to respond to external stimuli for the modulation of intracellular signaling events, leading to very different quantitative and qualitative functional outcomes.

Original languageEnglish
Pages (from-to)12-17
Number of pages6
JournalTrends in Immunology
Issue number1
Publication statusPublished - Jan 2008

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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