Reference values for ethylenethiourea in urine in Northern Italy: Results of a pilot study

Claudio Colosio; Sara Visentin; Sarah Birindelli; Laura Campo; Silvia Fustinoni; Franco Mariani; Manuela Tiramani; Michele Tommasini; Gabri Brambilla; Marco Maroni

doi:10.1016/j.toxlet.2005.09.031

Reference values for ethylenethiourea in urine in Northern Italy: Results of a pilot study

Claudio Colosio, Sara Visentin, Sarah Birindelli, Laura Campo, Silvia Fustinoni, Franco Mariani, Manuela Tiramani, Michele Tommasini, Gabri Brambilla, Marco Maroni

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

This study was carried out to define reference values for urinary ethylenethiourea (ETU) in the Northern Italy population and to identify the sources of exposure. Ninety-five healthy subjects were selected. A spot urine sample was collected in the morning, and analyzed using GC/MS in the EI/SIM mode. Thirty-nine subjects showed urinary ETU concentrations lower than the limit of detection (LOD, 0.4 μg/g creatinine), and the remainders ETU concentrations ranging from 0.5 to 11.6 μg/g creatinine. No correlation was shown between smoke or alcohol intake and urinary ETU concentrations. Based on data on ethylene-bis-dithiocarbamate (EBDC) concentrations in food, we estimated a total EBDCs intake of 31.7-50.1 μg/day. These values are largely below the ADIs, but explain the presence of small amounts of ETU in the urine samples we have analyzed. Finally, it was estimated that the mean ETU in urine in the Italian general population is 0.6-0.8 μg/g creatinine, with a 95th percentile of 4.5-5.0 μg/g creatinine. These values can be used as reference, to compare the results of biological monitoring activities carried out on EBDCs occupationally and environmentally exposed populations.

Original language	English
Pages (from-to)	153-157
Number of pages	5
Journal	Toxicology Letters
Volume	162
Issue number	2-3 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.toxlet.2005.09.031
Publication status	Published - Apr 10 2006

Keywords

Diet
Ethylene-bis-dithiocarbamates
Reference values
Urinary ethylenethiourea

ASJC Scopus subject areas

Toxicology

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10.1016/j.toxlet.2005.09.031

Cite this

@article{101e92f4a1ca43cabe429fffc3ebc592,

title = "Reference values for ethylenethiourea in urine in Northern Italy: Results of a pilot study",

abstract = "This study was carried out to define reference values for urinary ethylenethiourea (ETU) in the Northern Italy population and to identify the sources of exposure. Ninety-five healthy subjects were selected. A spot urine sample was collected in the morning, and analyzed using GC/MS in the EI/SIM mode. Thirty-nine subjects showed urinary ETU concentrations lower than the limit of detection (LOD, 0.4 μg/g creatinine), and the remainders ETU concentrations ranging from 0.5 to 11.6 μg/g creatinine. No correlation was shown between smoke or alcohol intake and urinary ETU concentrations. Based on data on ethylene-bis-dithiocarbamate (EBDC) concentrations in food, we estimated a total EBDCs intake of 31.7-50.1 μg/day. These values are largely below the ADIs, but explain the presence of small amounts of ETU in the urine samples we have analyzed. Finally, it was estimated that the mean ETU in urine in the Italian general population is 0.6-0.8 μg/g creatinine, with a 95th percentile of 4.5-5.0 μg/g creatinine. These values can be used as reference, to compare the results of biological monitoring activities carried out on EBDCs occupationally and environmentally exposed populations.",

keywords = "Diet, Ethylene-bis-dithiocarbamates, Reference values, Urinary ethylenethiourea",

author = "Claudio Colosio and Sara Visentin and Sarah Birindelli and Laura Campo and Silvia Fustinoni and Franco Mariani and Manuela Tiramani and Michele Tommasini and Gabri Brambilla and Marco Maroni",

year = "2006",

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T1 - Reference values for ethylenethiourea in urine in Northern Italy

T2 - Results of a pilot study

AU - Colosio, Claudio

AU - Visentin, Sara

AU - Birindelli, Sarah

AU - Campo, Laura

AU - Fustinoni, Silvia

AU - Mariani, Franco

AU - Tiramani, Manuela

AU - Tommasini, Michele

AU - Brambilla, Gabri

AU - Maroni, Marco

PY - 2006/4/10

Y1 - 2006/4/10

N2 - This study was carried out to define reference values for urinary ethylenethiourea (ETU) in the Northern Italy population and to identify the sources of exposure. Ninety-five healthy subjects were selected. A spot urine sample was collected in the morning, and analyzed using GC/MS in the EI/SIM mode. Thirty-nine subjects showed urinary ETU concentrations lower than the limit of detection (LOD, 0.4 μg/g creatinine), and the remainders ETU concentrations ranging from 0.5 to 11.6 μg/g creatinine. No correlation was shown between smoke or alcohol intake and urinary ETU concentrations. Based on data on ethylene-bis-dithiocarbamate (EBDC) concentrations in food, we estimated a total EBDCs intake of 31.7-50.1 μg/day. These values are largely below the ADIs, but explain the presence of small amounts of ETU in the urine samples we have analyzed. Finally, it was estimated that the mean ETU in urine in the Italian general population is 0.6-0.8 μg/g creatinine, with a 95th percentile of 4.5-5.0 μg/g creatinine. These values can be used as reference, to compare the results of biological monitoring activities carried out on EBDCs occupationally and environmentally exposed populations.

AB - This study was carried out to define reference values for urinary ethylenethiourea (ETU) in the Northern Italy population and to identify the sources of exposure. Ninety-five healthy subjects were selected. A spot urine sample was collected in the morning, and analyzed using GC/MS in the EI/SIM mode. Thirty-nine subjects showed urinary ETU concentrations lower than the limit of detection (LOD, 0.4 μg/g creatinine), and the remainders ETU concentrations ranging from 0.5 to 11.6 μg/g creatinine. No correlation was shown between smoke or alcohol intake and urinary ETU concentrations. Based on data on ethylene-bis-dithiocarbamate (EBDC) concentrations in food, we estimated a total EBDCs intake of 31.7-50.1 μg/day. These values are largely below the ADIs, but explain the presence of small amounts of ETU in the urine samples we have analyzed. Finally, it was estimated that the mean ETU in urine in the Italian general population is 0.6-0.8 μg/g creatinine, with a 95th percentile of 4.5-5.0 μg/g creatinine. These values can be used as reference, to compare the results of biological monitoring activities carried out on EBDCs occupationally and environmentally exposed populations.

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KW - Reference values

KW - Urinary ethylenethiourea

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Reference values for ethylenethiourea in urine in Northern Italy: Results of a pilot study

Abstract

Keywords

ASJC Scopus subject areas

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