Redox control of NLRP3 inflammasome activation in health and disease

Anna Rubartelli

Research output: Contribution to journalArticlepeer-review


Shifts in the redox balance between ROS and antioxidants regulate innate immunity at various levels. Changes in the redox microenvironment modulate the activation potential of the NLRP3 inflammasome, a signaling platform that activates caspase-1, allowing the maturation of IL-1β. However, a clear definition of the underlying mechanism is missing. In this essay, I review the most-credited theories on inflammasome activation. In particular, I will focus on the redox-mediated mechanisms that regulate the assembly of NLRP3 inflammasome and discuss how aberrations in them are implicated in the pathogenesis of autoinflammatory diseases.

Original languageEnglish
Pages (from-to)951-958
Number of pages8
JournalJournal of Leukocyte Biology
Issue number5
Publication statusPublished - Nov 2012


  • Antioxidants
  • Caspase-1
  • IL-1 receptor antagonist
  • IL-1β
  • Leaderless secretion
  • Oxidative stress
  • ROS

ASJC Scopus subject areas

  • Cell Biology
  • Immunology


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