Abstract
Shifts in the redox balance between ROS and antioxidants regulate innate immunity at various levels. Changes in the redox microenvironment modulate the activation potential of the NLRP3 inflammasome, a signaling platform that activates caspase-1, allowing the maturation of IL-1β. However, a clear definition of the underlying mechanism is missing. In this essay, I review the most-credited theories on inflammasome activation. In particular, I will focus on the redox-mediated mechanisms that regulate the assembly of NLRP3 inflammasome and discuss how aberrations in them are implicated in the pathogenesis of autoinflammatory diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 951-958 |
| Number of pages | 8 |
| Journal | Journal of Leukocyte Biology |
| Volume | 92 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Nov 2012 |
Keywords
- Antioxidants
- Caspase-1
- IL-1 receptor antagonist
- IL-1β
- Leaderless secretion
- Oxidative stress
- ROS
ASJC Scopus subject areas
- Cell Biology
- Immunology