TY - JOUR
T1 - Recommendations for detection and management of unsuitable samples in clinical laboratories
AU - Lippi, Giuseppe
AU - Banfi, Giuseppe
AU - Buttarello, Mauro
AU - Ceriotti, Ferruccio
AU - Daves, Massimo
AU - Dolci, Alberto
AU - Caputo, Marco
AU - Giavarina, Davide
AU - Montagnana, Martina
AU - Miconi, Valentino
AU - Milanesi, Bruno
AU - Mosca, Andrea
AU - Morandini, Margherita
AU - Salvagno, Gian Luca
PY - 2007/6/1
Y1 - 2007/6/1
N2 - A large body of evidence attests that quality programs developed around the analytical phase of the total testing process would only produce limited improvements, since the large majority of errors encountered in clinical laboratories still prevails within extra-analytical areas of testing, especially in manually intensive preanalytical processes. Most preanalytical errors result from system flaws and insufficient audit of the operators involved in specimen collection and handling responsibilities, leading to an unacceptable number of unsuitable specimens due to misidentification, in vitro hemolysis, clotting, inappropriate volume, wrong container or contamination from infusive routes. Detection and management of unsuitable samples are necessary to overcome this variability. The present document, issued by the Italian Inter-society SIBioC-SIMeL-CISMEL (Society of Clinical Biochemistry and Clinical Molecular Biology-Italian Society of Laboratory Medicine-Italian Committee for Standardization of Hematological and Laboratory Methods) Study Group on Extra-analytical Variability, reviews the major causes of unsuitable specimens in clinical laboratories, providing consensus recommendations for detection and management.
AB - A large body of evidence attests that quality programs developed around the analytical phase of the total testing process would only produce limited improvements, since the large majority of errors encountered in clinical laboratories still prevails within extra-analytical areas of testing, especially in manually intensive preanalytical processes. Most preanalytical errors result from system flaws and insufficient audit of the operators involved in specimen collection and handling responsibilities, leading to an unacceptable number of unsuitable specimens due to misidentification, in vitro hemolysis, clotting, inappropriate volume, wrong container or contamination from infusive routes. Detection and management of unsuitable samples are necessary to overcome this variability. The present document, issued by the Italian Inter-society SIBioC-SIMeL-CISMEL (Society of Clinical Biochemistry and Clinical Molecular Biology-Italian Society of Laboratory Medicine-Italian Committee for Standardization of Hematological and Laboratory Methods) Study Group on Extra-analytical Variability, reviews the major causes of unsuitable specimens in clinical laboratories, providing consensus recommendations for detection and management.
KW - Audit
KW - Detection of unsuitable specimens
KW - Extra-analytical variability
KW - Guidelines and consensus recommendations
KW - Laboratory errors
KW - Specimen collection
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U2 - 10.1515/CCLM.2007.174
DO - 10.1515/CCLM.2007.174
M3 - Article
C2 - 17579524
AN - SCOPUS:34250718143
SN - 1434-6621
VL - 45
SP - 728
EP - 736
JO - Clinical Chemistry and Laboratory Medicine
JF - Clinical Chemistry and Laboratory Medicine
IS - 6
ER -