Recombinant H-chain ferritins: Effects of changes in the 3-fold channels

Amyra Treffry, Pauline M. Harrison, Alessandra Luzzago, Gianni Cesareni

Research output: Contribution to journalArticlepeer-review


Human H-chain ferritins bearing sequence changes in the 3-fold channels have been expressed in E. coli to investigate the role of these channels in iron-storage processes. The proteins assemble into shells resembling those of native ferritins. Iron uptake measurements indicate that residues in the 3-fold channels are involved neither in initial Fe(II)-oxidation nor in iron-core nucleation.

Original languageEnglish
Pages (from-to)268-272
Number of pages5
JournalFEBS Letters
Issue number2
Publication statusPublished - Apr 24 1989


  • Ferritin
  • Ferritin channel
  • H chain
  • Iron storage
  • Iron(III)-apoferritin
  • Recombinant ferritin

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology


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