TY - JOUR
T1 - Receptor-mediated stimulation of inositol phospholipid hydrolysis in human brain
AU - Nicoletti, Ferdinando
AU - Canonico, Pier Luigi
AU - Favit, Antonella
AU - Nicoletti, Giovanni
AU - Albanese, Vincenzo
PY - 1989/1/31
Y1 - 1989/1/31
N2 - Stimulation of inositol phospolipid hydrolysis by transmitter receptor agonists was studied in slices from the occipital, temporal and cerebellar cortex that were surgically removed from three patients during ablation of brain tumors. Norepinephrine and the muscarinic acetylcholine agonist carbamylcholine increased the content of [3H]inositolmonophosphate (InsP) in all the regions examined, whereas the glutamate receptor agonist quisqualate was effective only in the cerebellar slices. These results provide evidence that neurotransmitter receptors are coupled to inositol phospholipid hydrolysis in human brain tissue.
AB - Stimulation of inositol phospolipid hydrolysis by transmitter receptor agonists was studied in slices from the occipital, temporal and cerebellar cortex that were surgically removed from three patients during ablation of brain tumors. Norepinephrine and the muscarinic acetylcholine agonist carbamylcholine increased the content of [3H]inositolmonophosphate (InsP) in all the regions examined, whereas the glutamate receptor agonist quisqualate was effective only in the cerebellar slices. These results provide evidence that neurotransmitter receptors are coupled to inositol phospholipid hydrolysis in human brain tissue.
KW - Brain (human)
KW - Carbachol
KW - Inositol phospholipids
KW - Norepinephrine
KW - Quisqualate
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U2 - 10.1016/0014-2999(89)90504-9
DO - 10.1016/0014-2999(89)90504-9
M3 - Article
C2 - 2547631
AN - SCOPUS:0024535286
SN - 0014-2999
VL - 160
SP - 299
EP - 301
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2
ER -