TY - JOUR
T1 - Recent advances in understanding Crohn's disease
AU - Sabatino, Antonio Di
AU - Rovedatti, Laura
AU - Vidali, Francesca
AU - MacDonald, Thomas Thornton
AU - Corazza, Gino Roberto
PY - 2013
Y1 - 2013
N2 - Crohn's disease is a chronic inflammatory bowel disorder resulting from an inappropriate innate and acquired immune response to commensal microorganisms in genetically susceptible individuals. This disease has a fluctuating course, with alternating periods of remission and relapses, and it is characterized by a remarkable clinical heterogeneity; it may be complicated by perianal fistulas, abscesses, and intestinal strictures leading to obstructions, besides several systemic manifestations. However, a complete resolution of the disease is currently not possible, yet Crohn's disease can be managed with established and novel therapies, which achieve long-term remission and acceptable quality of life. This review is focused on novel advances in basic and clinical aspects of Crohn's disease, although it also deals with new trends in diagnosis and treatment.
AB - Crohn's disease is a chronic inflammatory bowel disorder resulting from an inappropriate innate and acquired immune response to commensal microorganisms in genetically susceptible individuals. This disease has a fluctuating course, with alternating periods of remission and relapses, and it is characterized by a remarkable clinical heterogeneity; it may be complicated by perianal fistulas, abscesses, and intestinal strictures leading to obstructions, besides several systemic manifestations. However, a complete resolution of the disease is currently not possible, yet Crohn's disease can be managed with established and novel therapies, which achieve long-term remission and acceptable quality of life. This review is focused on novel advances in basic and clinical aspects of Crohn's disease, although it also deals with new trends in diagnosis and treatment.
KW - Chronic inflammation
KW - Fistula
KW - Inflammatory bowel disease
KW - Stricture
KW - Therapy
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U2 - 10.1007/s11739-011-0599-2
DO - 10.1007/s11739-011-0599-2
M3 - Article
C2 - 21553239
AN - SCOPUS:84874354114
SN - 1828-0447
VL - 8
SP - 101
EP - 113
JO - Internal and Emergency Medicine
JF - Internal and Emergency Medicine
IS - 2
ER -