Nuove strategie di prevenzione delle infezioni nel neonato pretermine

Translated title of the contribution: Recent advances in prevention of sepsis in the preterm neonate

Paolo Manzoni, Lidia Decembrino, Elena Gallo, Stefano Rizzollo, Caterina Franco, Michael Mostert, Mauro Stronati, Daniele Farina

Research output: Contribution to journalArticlepeer-review


An episode of sepsis occurs in 20 to 40% of all preterm patients, and such figures have been reported constantly increasing in Neonatal Intensive Care Units. Neonatal sepsis include bloodstream, urine, cerebrospinal, peritoneal infections, infections starting from burns and wounds, or from any other usually sterile sites. Many specific risk factors account for the increased risk of sepsis, including employment of broad-spectrum antibiotics selecting resistant microflora, parenteral nutrition, acid inhibitors and steroids, as well as the systematic and long-lasting use of invasive management. In preterm neonates, loss of gut commensals such as bifidobacteria and lactobacilli, due to the difficulties in oral feeding, or a slower acquisition of them, translates into an increased susceptibility to pathogenic gut colonization. Prompt diagnosis, effective treatment, and specific prophylaxis with antibacterial and antifungal drugs are the milestones of management of these life-threatening events. This article discusses the recent advances in prevention and shows how fluconazole for prevention of fungal sepsis, probiotics for prevention of necrotizing enterocolitis, and bovine lactoferrin for prevention of bacterial sepsis may be considered as effective preventive strategies.

Translated title of the contributionRecent advances in prevention of sepsis in the preterm neonate
Original languageItalian
Pages (from-to)483-489
Number of pages7
JournalRecenti Progressi in Medicina
Issue number12
Publication statusPublished - Dec 2010

ASJC Scopus subject areas

  • Medicine(all)


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