TY - JOUR
T1 - Rapidly progressive form of Creutzfeldt-Jakob disease without dementia
T2 - A case report
AU - Marciani, M. G.
AU - Bernardi, G.
AU - Sancesario, G.
AU - Gigli, G. L.
AU - Maschio, M.
AU - Palmieri, G.
AU - Schiaroli, S.
PY - 1996
Y1 - 1996
N2 - We describe a case of a patient with Creutzfeldt-Jakob disease (CJD) characterized by a rapid clinical course lasting one and a half months, by: presence of focal dystonic movements at onset, absence of mental deterioration in the period preceding the impairment of consciousness, ataxia, myoclonus and periodic EEG abnormalities. The autopsy confirmed subacute spongiform encephalopathy, but no evident neuronal loss was observed. An acute clinical course of CJD may explain this latter histological finding which, in turn, probably provides an explanation for the absence of intellectual impairment.
AB - We describe a case of a patient with Creutzfeldt-Jakob disease (CJD) characterized by a rapid clinical course lasting one and a half months, by: presence of focal dystonic movements at onset, absence of mental deterioration in the period preceding the impairment of consciousness, ataxia, myoclonus and periodic EEG abnormalities. The autopsy confirmed subacute spongiform encephalopathy, but no evident neuronal loss was observed. An acute clinical course of CJD may explain this latter histological finding which, in turn, probably provides an explanation for the absence of intellectual impairment.
KW - Cognitive impairment
KW - Creutzfeldt-Jakob disease
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M3 - Article
C2 - 8707472
AN - SCOPUS:0030075697
SN - 0020-7454
VL - 84
SP - 115
EP - 120
JO - International Journal of Neuroscience
JF - International Journal of Neuroscience
IS - 1-4
ER -