Abstract
A GLC method for the determination of valproic acid and ethosuximide in plasma was developed. The procedure involved a single solvent extraction of drugs from acidified plasma samples, followed by a GLC injection of the unconcentrated organic phase. This rapid, sensitive, specific, and reproducible method has been used for 2 years for the routine determination of plasma levels of valproic acid and ethosuximide in epileptic patients who receive other antiepileptic drugs simultaneously.
| Original language | English |
|---|---|
| Pages (from-to) | 110-111 |
| Number of pages | 2 |
| Journal | Journal of Pharmaceutical Sciences |
| Volume | 71 |
| Issue number | 1 |
| Publication status | Published - 1982 |
ASJC Scopus subject areas
- Molecular Medicine
- Chemistry(all)
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
- Pharmacology