Randomized crossover antiemetic study in cisplatin-treated patients - Comparison between high-dose IV metoclorpramide and high-dose IV dexamethasone

Sergio Frustaci; Enore Grattoni; Salvatore Tumolo; Diana Crivellari; Franco Figoli; Enzo Galligioni; Andrea Veronesi; Umberto Tirelli; Eligio Grigoletto

doi:10.1007/BF00299870

Randomized crossover antiemetic study in cisplatin-treated patients - Comparison between high-dose IV metoclorpramide and high-dose IV dexamethasone

Sergio Frustaci, Enore Grattoni, Salvatore Tumolo, Diana Crivellari, Franco Figoli, Enzo Galligioni, Andrea Veronesi, Umberto Tirelli, Eligio Grigoletto

Centro di Riferimento Oncologico

Research output: Contribution to journal › Article › peer-review

Abstract

This prospective, randomized, nonblind study comparing the antiemetic effectiveness of high-dose IV metoclopramide and high-dose IV dexamthasone was performed in 78 advanced cancer patients. Chemotherapeutic treatment consisted in cisplatin at a high-dose (120 mg/m²) (HD-CDDP) and at a low-dose (LD-CDDP), either alone (60 mg/m²) or in combination with other chemotherapeutic agents (50 mg/m²). The evaluation of the effectiveness of antiemetic therapy was based on three parameters: prevention of vomiting ("major protection"), number of emetic episodes, and subjective preference. Out of 78 study patients, 67 were evaluable. Overall, metoclopramide proved to be statistically superior to dexamethasone in preventing vomiting (P

Original language	English
Pages (from-to)	75-79
Number of pages	5
Journal	Cancer Chemotherapy and Pharmacology
Volume	17
Issue number	1
DOIs	https://doi.org/10.1007/BF00299870
Publication status	Published - May 1986

ASJC Scopus subject areas

Pharmacology
Oncology
Cancer Research

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Frustaci, S., Grattoni, E., Tumolo, S., Crivellari, D., Figoli, F., Galligioni, E., Veronesi, A., Tirelli, U., & Grigoletto, E. (1986). Randomized crossover antiemetic study in cisplatin-treated patients - Comparison between high-dose IV metoclorpramide and high-dose IV dexamethasone. Cancer Chemotherapy and Pharmacology, 17(1), 75-79. https://doi.org/10.1007/BF00299870

Frustaci, S, Grattoni, E, Tumolo, S, Crivellari, D, Figoli, F, Galligioni, E, Veronesi, A, Tirelli, U & Grigoletto, E 1986, 'Randomized crossover antiemetic study in cisplatin-treated patients - Comparison between high-dose IV metoclorpramide and high-dose IV dexamethasone', Cancer Chemotherapy and Pharmacology, vol. 17, no. 1, pp. 75-79. https://doi.org/10.1007/BF00299870

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AU - Grattoni, Enore

AU - Tumolo, Salvatore

AU - Crivellari, Diana

AU - Figoli, Franco

AU - Galligioni, Enzo

AU - Veronesi, Andrea

AU - Tirelli, Umberto

AU - Grigoletto, Eligio

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Randomized crossover antiemetic study in cisplatin-treated patients - Comparison between high-dose IV metoclorpramide and high-dose IV dexamethasone

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