RalB Signaling: A Bridge between Inflammation and Cancer

Alberto Mantovani; Frances Balkwill

doi:10.1016/j.cell.2006.09.019

RalB Signaling: A Bridge between Inflammation and Cancer

Alberto Mantovani, Frances Balkwill

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

A connection between the genetic events that lead to tumor formation and the signaling pathways of the innate immune response has been established. In this issue, Chien et al. (2006) show that the RalB GTPase regulates the IKK family member TBK1, providing an unexpected link between the signaling pathways that promote inflammation and cancer. In tumor cells the RalB/TBK1 pathway inhibits apoptosis and in nontumorigenic cells it stimulates an innate immune response.

Original language	English
Pages (from-to)	42-44
Number of pages	3
Journal	Cell
Volume	127
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2006.09.019
Publication status	Published - Oct 6 2006

ASJC Scopus subject areas

Cell Biology
Molecular Biology

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10.1016/j.cell.2006.09.019

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title = "RalB Signaling: A Bridge between Inflammation and Cancer",

abstract = "A connection between the genetic events that lead to tumor formation and the signaling pathways of the innate immune response has been established. In this issue, Chien et al. (2006) show that the RalB GTPase regulates the IKK family member TBK1, providing an unexpected link between the signaling pathways that promote inflammation and cancer. In tumor cells the RalB/TBK1 pathway inhibits apoptosis and in nontumorigenic cells it stimulates an innate immune response.",

author = "Alberto Mantovani and Frances Balkwill",

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RalB Signaling: A Bridge between Inflammation and Cancer

Abstract

ASJC Scopus subject areas

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