Radiotherapy of mycosis fungoides 'minimal disease': A report of 7 cases

The definition of a subset of stage IA mycosis fungoides as minimal disease, when it is made up by a single lesion or few close lesions, permits to speculate if a really 'curative' treatment does exist. Radiotherapy has been proposed as one of the most suitable therapies. A retrospective study was conducted on a series of 7 patients with MF 'minimal disease' treated by dermatological radiotherapy with 9 fields of irradiation. On the whole, complete remission was obtained in 8 fields (88%) and a partial remission in one (12%). Up to now (median follow-up of 72 months), 4 cases out of 7 are disease free, while the other 3 show persistence of the disease (2 outside the irradiation field) in a localized form. No case developed a more advanced disease nor extracutaneous involvement. No complications nor sequelae of radiotherapy were observed. Our results are encouraging and suggest to enlarge the casuistic further.