Radiosurgery for intracranial meningiomas: A systematic review and meta-analysis

Valentina Pinzi, Elena Biagioli, Anna Roberto, Francesca Galli, Michele Rizzi, Federica Chiappa, Greta Brenna, Laura Fariselli, Irene Floriani

Research output: Contribution to journalReview articlepeer-review


Background Radiosurgery(RS), both in single and multiple sessions, have been performed for intracranial meningiomas. Different aspects are still controversial on this field. The aim of this systematic review is to summarize the current literature on long-term efficacy and safety of RS for meningiomas. Methods Online databases were searched for studies published until April 2015. The primary outcomes were disease control and progression-free-survival(PFS). The secondary outcomes were symptom control and radiation-induced toxicity. Results The estimate of disease control rate ranged from 87.0% to 100.0% at 5 years and from 67.0% to 100.0% at 10 years. The PFS rate ranged 78.0%–98.9% and 53.1%–97.2% at 5 and 10 years, respectively. The overall symptom control was 92.3%, the overall toxicity was 8.1%. Conclusions RS can be considered a safe and effective treatment. Efforts are needed in standardizing the definition of local and symptom control and toxicity in order to properly compare different treatment schedules.

Original languageEnglish
Pages (from-to)122-134
Number of pages13
JournalCritical Reviews in Oncology/Hematology
Publication statusPublished - May 1 2017


  • Hypo-fractionated stereotactic radiotherapy
  • Intracranial meningioma
  • Radiosurgery
  • Staged radiosurgery
  • WHO I meningioma
  • WHO II meningioma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Geriatrics and Gerontology


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