Radiomics and “radi-…omics” in cancer immunotherapy: a guide for clinicians

Michele Porcu, Cinzia Solinas, Lorenzo Mannelli, Giulio Micheletti, Matteo Lambertini, Karen Willard-Gallo, Emanuele Neri, Adam E. Flanders, Luca Saba

Research output: Contribution to journalReview articlepeer-review


In recent years the concept of precision medicine has become a popular topic particularly in medical oncology. Besides the identification of new molecular prognostic and predictive biomarkers and the development of new targeted and immunotherapeutic drugs, imaging has started to play a central role in this new era. Terms such as “radiomics”, “radiogenomics” or “radi…-omics” are becoming increasingly common in the literature and soon they will represent an integral part of clinical practice. The use of artificial intelligence, imaging and “-omics” data can be used to develop models able to predict, for example, the features of the tumor immune microenvironment through imaging, and to monitor the therapeutic response beyond the standard radiological criteria. The aims of this narrative review are to provide a simplified guide for clinicians to these concepts, and to summarize the existing evidence on radiomics and “radi…-omics” in cancer immunotherapy.

Original languageEnglish
Article number103068
JournalCritical Reviews in Oncology/Hematology
Publication statusPublished - Oct 2020


  • cancer immunotherapy
  • CTLA-4
  • immune checkpoint blockade
  • immune checkpoint molecules
  • PD-1/PD-L1
  • Radiomics

ASJC Scopus subject areas

  • Hematology
  • Oncology


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