TY - JOUR
T1 - Radiomics and “radi-…omics” in cancer immunotherapy
T2 - a guide for clinicians
AU - Porcu, Michele
AU - Solinas, Cinzia
AU - Mannelli, Lorenzo
AU - Micheletti, Giulio
AU - Lambertini, Matteo
AU - Willard-Gallo, Karen
AU - Neri, Emanuele
AU - Flanders, Adam E.
AU - Saba, Luca
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/10
Y1 - 2020/10
N2 - In recent years the concept of precision medicine has become a popular topic particularly in medical oncology. Besides the identification of new molecular prognostic and predictive biomarkers and the development of new targeted and immunotherapeutic drugs, imaging has started to play a central role in this new era. Terms such as “radiomics”, “radiogenomics” or “radi…-omics” are becoming increasingly common in the literature and soon they will represent an integral part of clinical practice. The use of artificial intelligence, imaging and “-omics” data can be used to develop models able to predict, for example, the features of the tumor immune microenvironment through imaging, and to monitor the therapeutic response beyond the standard radiological criteria. The aims of this narrative review are to provide a simplified guide for clinicians to these concepts, and to summarize the existing evidence on radiomics and “radi…-omics” in cancer immunotherapy.
AB - In recent years the concept of precision medicine has become a popular topic particularly in medical oncology. Besides the identification of new molecular prognostic and predictive biomarkers and the development of new targeted and immunotherapeutic drugs, imaging has started to play a central role in this new era. Terms such as “radiomics”, “radiogenomics” or “radi…-omics” are becoming increasingly common in the literature and soon they will represent an integral part of clinical practice. The use of artificial intelligence, imaging and “-omics” data can be used to develop models able to predict, for example, the features of the tumor immune microenvironment through imaging, and to monitor the therapeutic response beyond the standard radiological criteria. The aims of this narrative review are to provide a simplified guide for clinicians to these concepts, and to summarize the existing evidence on radiomics and “radi…-omics” in cancer immunotherapy.
KW - cancer immunotherapy
KW - CTLA-4
KW - immune checkpoint blockade
KW - immune checkpoint molecules
KW - PD-1/PD-L1
KW - Radiomics
UR - http://www.scopus.com/inward/record.url?scp=85089440951&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85089440951&partnerID=8YFLogxK
U2 - 10.1016/j.critrevonc.2020.103068
DO - 10.1016/j.critrevonc.2020.103068
M3 - Review article
C2 - 32805498
AN - SCOPUS:85089440951
SN - 1040-8428
VL - 154
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
M1 - 103068
ER -