Radiofrequency ablation of hepatocellular carcinoma

S. A. Curley, F. Izzo

Research output: Contribution to journalArticlepeer-review


The majority of patients with primary or metastatic hepatic tumors are not candidates for resection because of tumor size, location near major intrahepatic blood vessels precluding a margin-negative resection, multifocality, or inadequate hepatic function related to coexistent cirrhosis. Radiofrequency ablation (RFA) is an evolving technology being used to treat patients with unresectable primary and metastatic hepatic cancers. RFA produces coagulative necrosis of tumor through local tissue heating. Liver tumors are treated percutaneously, laparoscopically, or during laparotomy using ultrasonography to identify tumors and to guide placement of the RFA needle electrode. For tumors smaller than 2.0 cm in diameter, one or two deployments of the monopolar multiple array needle electrode is sufficient to produce complete coagulative necrosis of the tumor. However, with increasing size of the tumor, there is a concomitant increase in the number of deployments of the needle electrode and the overall time necessary to produce complete coagulative necrosis of the tumor. In general, RFA is a safe, well-tolerated, effective treatment for unresectable hepatic malignancies less than 6.0 cm in diameter. Effective treatment of larger tumors awaits the development of more powerful, larger array monopolar and bipolar RFA technologies.

Original languageEnglish
Pages (from-to)165-176
Number of pages12
JournalMinerva Chirurgica
Issue number2
Publication statusPublished - 2002


  • Carcinoma, hepatocellular, therapy
  • Catheter ablation
  • Liver neoplasms, secondary, therapy
  • Liver neoplasms, therapy

ASJC Scopus subject areas

  • Surgery


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